(5-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentane-1-sulfinylamino)-acetic acid ethyl ester

Base Information

Chemical Name:(5-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentane-1-sulfinylamino)-acetic acid ethyl ester
CAS No.:274901-42-7
Molecular Formula:C₂₂H₃₅N₃O₇S
Molecular Weight:485.602
Hs Code.:

(5-benzyloxycarbonylamino-2-<i>tert</i>-butoxycarbonylamino-pentane-1-sulfinylamino)-acetic acid ethyl ester

Synonyms:(5-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentane-1-sulfinylamino)-acetic acid ethyl ester

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Chemical Property of (5-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentane-1-sulfinylamino)-acetic acid ethyl ester

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Technology Process of (5-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentane-1-sulfinylamino)-acetic acid ethyl ester

There total 5 articles about (5-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentane-1-sulfinylamino)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 623-33-6
glycine ethyl ester hydrochloride

: 274901-40-5
(4-tert-butoxycarbonylamino-5-chlorosulfinyl-pentyl)-carbamic acid benzyl ester

: 274901-42-7
(5-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentane-1-sulfinylamino)-acetic acid ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1002/1099-0690(200004)2000:7<1219::AID-EJOC1219>3.0.CO;2-P

Reference yield:

: 2480-93-5
Boc-Orn(Z)-OH

: 274901-42-7
(5-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentane-1-sulfinylamino)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethyl chloroformate / tetrahydrofuran / 0.25 h / -10 - 0 °C

1.2: 83 percent / NaBH₄ / tetrahydrofuran; methanol / 0 °C

2.1: 80 percent / triethylamine / CH₂Cl₂ / 1.5 h / 0 - 20 °C

3.1: 69 percent / Cs₂CO₃ / dimethylformamide / 0 °C

4.1: sulfuryl chloride; acetic anhydride / CH₂Cl₂ / 1 h / -20 - -5 °C

5.1: 78 percent / triethylamine / CH₂Cl₂ / 0 °C

With sulfuryl dichloride; chloroformic acid ethyl ester; acetic anhydride; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Substitution / 1.2: Reduction / 2.1: Substitution / 3.1: Substitution / 4.1: Deacetylation / 5.1: Condensation;
DOI:10.1002/1099-0690(200004)2000:7<1219::AID-EJOC1219>3.0.CO;2-P

Reference yield:

: 105562-75-2
N²-(tert-butyloxycarbonyl)-N⁵-(benzyloxycarbonyl)-2(S),5-diaminopentanol

: 274901-42-7
(5-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentane-1-sulfinylamino)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / triethylamine / CH₂Cl₂ / 1.5 h / 0 - 20 °C

2: 69 percent / Cs₂CO₃ / dimethylformamide / 0 °C

3: sulfuryl chloride; acetic anhydride / CH₂Cl₂ / 1 h / -20 - -5 °C

4: 78 percent / triethylamine / CH₂Cl₂ / 0 °C

With sulfuryl dichloride; acetic anhydride; caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Substitution / 3: Deacetylation / 4: Condensation;
DOI:10.1002/1099-0690(200004)2000:7<1219::AID-EJOC1219>3.0.CO;2-P