105562-75-2Relevant academic research and scientific papers
HIGHLY ACTIVE STING PROTEIN AGONIST COMPOUND
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Paragraph 0120-0122, (2021/07/17)
The present invention provides compounds of Formula (I) or (II), pharmaceutical compositions thereof, and methods of using compounds of Formula (I) or (II) to prevent and/or treat immune-related disorders.
FUSED TRICYCLIC HETEROCYCLE COMPOUNDS AND THERAPEUTIC USES THEREOF
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Page/Page column 60-61, (2020/01/24)
This application discloses a new class of fused tricyclic heterocycles of formula (I), preparation methods thereof, pharmaceutical compositions comprising these compounds, and pharmaceutically acceptable salts, solvates, or prodrugs thereof, and their use
Synthesis of protected 3-aminopiperidine and 3-aminoazepane derivatives using enzyme cascades
Baldwin, Christopher R.,Birmingham, William R.,Flitsch, Sabine L.,Ford, Grayson J.,Hepworth, Lorna J.,Huang, Min,Kress, Nico,Marshall, James R.,Mattey, Ashley P.,Seibt, Lisa S.,Turner, Nicholas J.
supporting information, p. 7949 - 7952 (2020/09/09)
Multi-enzyme cascades utilising variants of galactose oxidase and imine reductase led to the successful conversion of N-Cbz-protected l-ornithinol and l-lysinol to l-3-N-Cbz-aminopiperidine and l-3-N-Cbz-aminoazepane respectively, in up to 54% isolated yi
Novel acyl-dipeptide-like compounds, a method for preparing the same and pharmaceutical compositions containing such products
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Page/Page column 6, (2008/06/13)
The invention relates to the field of chemistry and more specifically to the field of medicinal chemistry. The invention is directed to N-acyl-dipeptide-like compounds having the general formula I wherein substituents A, B, X, Y, R1, R2, and subscripts n, m, p and q have the same meanings as those given in the claims. The invention is equally directed to pharmaceutical compositions containing as an active ingredient at least one compound of general formula I either in acid or salt form with an organic or mineral base. The compounds persuant to the invention display interesting pharmacological properties which make them useful as drugs.
PEPTIDOMIMETICS SELECTIVE FOR THE SOMATOSTATIN RECEPTOR SUBTYPES 1 AND/OR 4
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Page/Page column 58, (2010/11/24)
The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein A, D, E, J, Q1 R1 , R2, R3, p and j are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) possess high affinity and selectivity for the somatostatin receptor subtypes sst1 and/or sst4 and can be used for the treatment or diagnosis of diseases or conditions wherein sst1 and/or sst4 agonists or antagonists are indicated to be useful.
Synthesis of the Unnatural Amino Acid AGDHE, a Constituent of the Cyclic Depsipeptides Callipeltins A and D
Thoen, Jason C.,Morales-Ramos, Angel I.,Lipton, Mark A.
, p. 4455 - 4458 (2007/10/03)
(Matrix Presented) The novel amino acid residue (2R,3R,4S)-4-amido-7-guanidino-2,3-dihydroxyheptanoic acid (AGDHE, 3), a constituent of the cyclic depsipeptides callipeltins A and D, and its (2S,3S,4S) diastereomer were synthesized from a protected L-orni
Synthesis of α- and β-substituted aminoethane sulfonamide arginine- glycine mimics
Lowik, Dennis W.P.M.,Liskamp, Rob M.J.
, p. 1219 - 1228 (2007/10/03)
In this paper we present a synthesis of both α- and β-substituted aminoethane sulfonamide arginine mimics. The α-substituted sulfonamides were obtained starting from an alkene, whereas the β-substituted sulfonamides were derived from an amino acid derivative.
Inhibition of Aspartic Proteinases by Peptides Containing Lysine and Ornithine Side-Chain Analogues of Statine
Salituro, Francesco G.,Agarwal, Nirankar,Hofmann, Theo,Rich, Daniel H.
, p. 286 - 295 (2007/10/02)
The synthesis of two new analogues of statine are reported corresponding to analogues with the lysine side-chain and the ornithine side chain.These analogues were designed on the basis of substrate specificity and molecular modeling of three-dimensional s
