N-(3-{2-(1,1-dimethylethyl)-5-[2-(3-hydroxypropyl)-4-pyrimidinyl]-1,3-thiazol-4-yl}-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

Base Information

Chemical Name:N-(3-{2-(1,1-dimethylethyl)-5-[2-(3-hydroxypropyl)-4-pyrimidinyl]-1,3-thiazol-4-yl}-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
CAS No.:1195767-29-3
Molecular Formula:C₂₆H₂₅F₃N₄O₃S₂
Molecular Weight:562.637
Hs Code.:

Synonyms:N-(3-{2-(1,1-dimethylethyl)-5-[2-(3-hydroxypropyl)-4-pyrimidinyl]-1,3-thiazol-4-yl}-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

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Chemical Property of N-(3-{2-(1,1-dimethylethyl)-5-[2-(3-hydroxypropyl)-4-pyrimidinyl]-1,3-thiazol-4-yl}-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

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Technology Process of N-(3-{2-(1,1-dimethylethyl)-5-[2-(3-hydroxypropyl)-4-pyrimidinyl]-1,3-thiazol-4-yl}-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

There total 10 articles about N-(3-{2-(1,1-dimethylethyl)-5-[2-(3-hydroxypropyl)-4-pyrimidinyl]-1,3-thiazol-4-yl}-2-fluorophenyl)-2,6-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1195768-23-0
N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1 ,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

: 107-18-6
allyl alcohol

: 1195767-29-3
N-(3-{2-(1,1-dimethylethyl)-5-[2-(3-hydroxypropyl)-4-pyrimidinyl]-1,3-thiazol-4-yl}-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

Guidance literature:: allyl alcohol; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; at 0 ℃; Cooling with ice;

N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1 ,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide; With potassium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; at 50 ℃;

Reference yield:

: 206551-41-9
2-fluoro-3-bromobenzoic acid methyl ester

: 1195767-29-3
N-(3-{2-(1,1-dimethylethyl)-5-[2-(3-hydroxypropyl)-4-pyrimidinyl]-1,3-thiazol-4-yl}-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: pyridine / dichloromethane / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Cooling with ice-water

5.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C

5.2: 20 - 80 °C

6.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 °C / Cooling with ice

6.2: 50 °C

With pyridine; N-Bromosuccinimide; caesium carbonate; 9-bora-bicyclo[3.3.1]nonane; trifluoroacetic acid; lithium hexamethyldisilazane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; toluene;

Reference yield:

: 946126-94-9
2-fluoro-3-nitrobenzoic acid methyl ester

: 1195767-29-3
N-(3-{2-(1,1-dimethylethyl)-5-[2-(3-hydroxypropyl)-4-pyrimidinyl]-1,3-thiazol-4-yl}-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / nickel / tetrahydrofuran; methanol; water / 70 °C

2.1: pyridine / dichloromethane / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Cooling with ice-water

4.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C

4.2: 20 - 80 °C

5.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 °C / Cooling with ice

5.2: 50 °C

With pyridine; N-Bromosuccinimide; hydrazine hydrate; 9-bora-bicyclo[3.3.1]nonane; lithium hexamethyldisilazane; nickel; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water;