8,10-bis(4-chlorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[1,2-a][1,3]diazepin-6-ylium bromide

Base Information

Chemical Name:8,10-bis(4-chlorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[1,2-a][1,3]diazepin-6-ylium bromide
CAS No.:1345840-47-2
Molecular Formula:Br*C₂₁H₁₉Cl₂N₂
Molecular Weight:450.205
Hs Code.:

Synonyms:8,10-bis(4-chlorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[1,2-a][1,3]diazepin-6-ylium bromide

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Chemical Property of 8,10-bis(4-chlorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[1,2-a][1,3]diazepin-6-ylium bromide

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Technology Process of 8,10-bis(4-chlorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[1,2-a][1,3]diazepin-6-ylium bromide

There total 2 articles about 8,10-bis(4-chlorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[1,2-a][1,3]diazepin-6-ylium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1345840-37-0
8,10-dibromo-2,3,4,5-tetrahydro-1H-pyrido[1,2-a][1,3]diazepin-6-ylium bromide

: 1679-18-1
4-Chlorophenylboronic acid

: 1345840-47-2
8,10-bis(4-chlorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[1,2-a][1,3]diazepin-6-ylium bromide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 0.0666667h; Inert atmosphere; Microwave irradiation;
DOI:10.1055/s-0030-1261033

Reference yield:

: 35486-42-1
2-amino-3,5-dibromopyridine

: 1345840-47-2
8,10-bis(4-chlorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[1,2-a][1,3]diazepin-6-ylium bromide

Guidance literature:: Multi-step reaction with 2 steps

1: basic alumina / 0.08 h / 90 °C / Microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 0.07 h / 80 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; 2: Suzuki-Miyaura cross-coupling reaction;
DOI:10.1055/s-0030-1261033