2-Methoxy-3-methylaniline

Base Information

• Chemical Name: 2-Methoxy-3-methylaniline
• CAS No.: 18102-30-2
• Molecular Formula: C8H11 N O
• Molecular Weight: 137.181
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID20495171
• Nikkaji Number: J141.480A
• Wikidata: Q82343134
• Mol file: 18102-30-2.mol

Synonyms:2-Methoxy-3-methylaniline;18102-30-2;Benzenamine, 2-methoxy-3-methyl-;MFCD12547890;2amino-6-methylanisole;2-Amino-6-methylanisole;3-Amino-2-methoxytoluene;SCHEMBL1709964;DTXSID20495171;AKOS006346340;FS-4971;SY275271;CS-0153684;D94564;A853767

Chemical Property of 2-Methoxy-3-methylaniline

Chemical Property:

• PSA: 35.25000
• LogP: 2.16700
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-3-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=CC=C1)N)OC
• Uses: 2-Methoxy-3-methylaniline is an important building block.

Technology Process of 2-Methoxy-3-methylaniline

There total 8 articles about 2-Methoxy-3-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-methyl-6-nitroanisole (18102-29-9) → 2-methoxy-3-methylaniline (18102-30-2)

Guidance literature:

With iron; acetic acid; In water; at 23 ℃; for 17h; Schlenk technique; Inert atmosphere;

DOI:10.1007/s00706-021-02844-1

Reference yield:

2-methylmethoxybenzene (578-58-5) + C8H15N3O3 → 2-methoxy-3-methylaniline (18102-30-2) + 4-methoxy-3-methylaniline (136-90-3)

Guidance literature:

2-methylmethoxybenzene; C₈H₁₅N₃O₃; With tin(IV) chloride; at 20 ℃;

With cesium hydroxide; In ethylene glycol; at 160 ℃; for 4h; Title compound not separated from byproducts;

DOI:10.1246/cl.2003.548

Reference yield:

2-methyl-6-nitrophenol (13073-29-5) → 2-methoxy-3-methylaniline (18102-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 63 h / 23 °C / Schlenk technique; Inert atmosphere

2: acetic acid; iron / water / 17 h / 23 °C / Schlenk technique; Inert atmosphere

With iron; potassium carbonate; acetic acid; In water; N,N-dimethyl-formamide; 1: |Williamson Ether Synthesis;

DOI:10.1007/s00706-021-02844-1

upstream raw materials:

2-methyl-6-nitroanisole

hydrogenchloride

1-(2-methoxy-3-methyl-phenyl)-ethanone oxime

2-methylmethoxybenzene

Downstream raw materials:

acetic acid-(2-methoxy-3-methyl-anilide)

2-methyl-6-iodoanisole

2?hydroxy?3?methoxy?4?methylbenzaldehyde

2-methoxy-3-methyl-N,N-bis(2-methoxyphenyl)-aniline