Ethyl 4-hydroxy-2-oxo-3-phenyl-1,2-dihydroquinoline-5-carboxylate

Base Information

Chemical Name:Ethyl 4-hydroxy-2-oxo-3-phenyl-1,2-dihydroquinoline-5-carboxylate
CAS No.:1207455-16-0
Molecular Formula:C₁₈H₁₅NO₄
Molecular Weight:309.321
Hs Code.:

Synonyms:Ethyl 4-hydroxy-2-oxo-3-phenyl-1,2-dihydroquinoline-5-carboxylate

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Chemical Property of Ethyl 4-hydroxy-2-oxo-3-phenyl-1,2-dihydroquinoline-5-carboxylate

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Technology Process of Ethyl 4-hydroxy-2-oxo-3-phenyl-1,2-dihydroquinoline-5-carboxylate

There total 6 articles about Ethyl 4-hydroxy-2-oxo-3-phenyl-1,2-dihydroquinoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1207455-15-9
ethyl 4-hydroxy-1-(4-methoxybenzyl)-2-oxo-3-phenyl-1,2-dihydroquinoline-5-carboxylate

: 1207455-16-0
Ethyl 4-hydroxy-2-oxo-3-phenyl-1,2-dihydroquinoline-5-carboxylate

Guidance literature:: With trifluoroacetic acid; for 48h; Reflux;

Reference yield:

: 641-70-3
3-nitrophthalic acid anhydride

: 1207455-16-0
Ethyl 4-hydroxy-2-oxo-3-phenyl-1,2-dihydroquinoline-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 °C

1.2: pH 1

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

3.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 20 °C

3.2: pH 6 - 7

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 20 °C

4.2: 30 °C

4.3: pH 3 - 4

5.1: sodium sulfate / ethanol / 18 h / 20 °C

6.1: triethylamine / 48 h / Reflux

With sodium tetrahydroborate; hydrogen; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium sulfate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 65399-18-0
4-nitrophthalide

: 1207455-16-0
Ethyl 4-hydroxy-2-oxo-3-phenyl-1,2-dihydroquinoline-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

2.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 20 °C

2.2: pH 6 - 7

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 20 °C

3.2: 30 °C

3.3: pH 3 - 4

4.1: sodium sulfate / ethanol / 18 h / 20 °C

5.1: triethylamine / 48 h / Reflux

With hydrogen; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium sulfate; triethylamine; palladium 10% on activated carbon; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;