(2R,5S)-2-Benzyloxymethyl-5-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(2R,5S)-2-Benzyloxymethyl-5-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:159516-88-8
Molecular Formula:C₁₈H₂₅NO₄
Molecular Weight:319.401
Hs Code.:

Synonyms:(2R,5S)-2-Benzyloxymethyl-5-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Suppliers and Price of (2R,5S)-2-Benzyloxymethyl-5-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,5S)-2-Benzyloxymethyl-5-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,5S)-2-Benzyloxymethyl-5-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 18 articles about (2R,5S)-2-Benzyloxymethyl-5-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 159516-87-7
(2R,5S)-2-Benzyloxymethyl-5-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 159516-88-8
(2R,5S)-2-Benzyloxymethyl-5-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.25h;
DOI:10.1016/S0040-4020(01)80643-8

Reference yield: 65.0%

: 159516-83-3
(2R,5S)-2-Benzyloxymethyl-5-cyano-pyrrolidine-1-carboxylic acid tert-butyl ester

: 159516-88-8
(2R,5S)-2-Benzyloxymethyl-5-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 1h;
DOI:10.1016/S0040-4020(01)80643-8

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 159516-88-8
(2R,5S)-2-Benzyloxymethyl-5-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / 4-dimethylaminopyridine / acetonitrile; triethylamine / 3 h / Ambient temperature

2: diisobutylaluminium hydride / hexane; tetrahydrofuran / -78 deg C, 1 h, then 0 deg C, 2 h

3: pyridinium p-toluenesulfonate / 12 h / Ambient temperature

4: NaH / paraffin; dimethylformamide / 1 h / Ambient temperature

5: 68 percent / boron trifluoride etherate / CH₂Cl₂ / 1 h / -78 °C

6: 62 percent / diisobutylaluminium hydride / toluene / 1 h / -78 °C

7: 1.) potassium carbonate; 2.) sodium borohydride / 1.) methanol, reflux, 2 h; 2.) methanol, room temp., 30 min

8: 99 percent / dimethyl sulfoxide, oxalyl chloride / CH₂Cl₂ / 0.25 h / -78 °C

With dmap; sodium tetrahydroborate; oxalyl dichloride; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; In tetrahydrofuran; hexane; dichloromethane; triethylamine; N,N-dimethyl-formamide; toluene; acetonitrile; paraffin;
DOI:10.1016/S0040-4020(01)80643-8