159516-83-3

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 73915-05-6 (R)-N-(4-methoxybenzyl)glutamic acid 
• 159411-92-4 (R)-5-Benzyloxymethyl-1-(4-methoxy-benzyl)-pyrrolidin-2-one 
• 159411-90-2 (R)-5-ethoxycarbonyl-1-(4-methoxybenzyl)-2-pyrrolidinone 
• 1010807-82-5 1‐(tert‐butyl) 2‐methyl (2R)‐5‐methoxypyrrolidine‐1,2‐dicarboxylate 
• 159411-91-3 (5R)-5-(hydroxymethyl)-1-(4-methoxybenzyl)pyrrolidin-2-one 
• 159411-93-5 (R)-5-Benzyloxymethyl-pyrrolidin-2-one 
• 107640-69-7 (R)-N-t-butoxycarbonyl-5-benzyloxymethyl-2-pyrrolidinone 
• 100-39-0 benzyl bromide 
• 64700-65-8 methyl (2R)-pyroglutamate 
• 128811-48-3 1‐(tert‐butyl) 2‐methyl (R)‐5‐oxopyrrolidine‐1,2‐dicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 6893-26-1 D-Glutamic acid 

Downstream Products

• 159516-88-8 (2R,5S)-2-Benzyloxymethyl-5-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthetic studies on quinocarcin and its related compounds. 3. Synthesis of 5-substituted- and 3,5-disubstituted-2-formyl-pyrrolidine derivatives, the key D-ring fragments of enantiomeric pairs of quinocarcin and 1

The title synthesis was accomplished by employing each enantiomer of glutamic acid and pyroglutamic acid as chiral starting materials.