2-[4-t-Butoxycarbonyl-(2 R)-(3,4-dichlorophenyl)morpholin-2-yl]ethanol t-butyldimethylsilyl ether

Base Information

Chemical Name:2-[4-t-Butoxycarbonyl-(2 R)-(3,4-dichlorophenyl)morpholin-2-yl]ethanol t-butyldimethylsilyl ether
CAS No.:191673-60-6
Molecular Formula:C₂₃H₃₇Cl₂NO₄Si
Molecular Weight:490.543
Hs Code.:

Synonyms:2-[4-t-Butoxycarbonyl-(2 R)-(3,4-dichlorophenyl)morpholin-2-yl]ethanol t-butyldimethylsilyl ether

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Chemical Property of 2-[4-t-Butoxycarbonyl-(2 R)-(3,4-dichlorophenyl)morpholin-2-yl]ethanol t-butyldimethylsilyl ether

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 2-[4-t-Butoxycarbonyl-(2 R)-(3,4-dichlorophenyl)morpholin-2-yl]ethanol t-butyldimethylsilyl ether

There total 12 articles about 2-[4-t-Butoxycarbonyl-(2 R)-(3,4-dichlorophenyl)morpholin-2-yl]ethanol t-butyldimethylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 191673-50-4
[(R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(3,4-dichloro-phenyl)-2-hydroxy-butyl]-(2-hydroxy-ethyl)-carbamic acid tert-butyl ester

: 191673-60-6
2-[4-t-Butoxycarbonyl-(2 R)-(3,4-dichlorophenyl)morpholin-2-yl]ethanol t-butyldimethylsilyl ether

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; Ambient temperature;
DOI:10.1016/S0957-4166(98)00336-X

Reference yield:

: 191673-32-2
(R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(3,4-dichloro-phenyl)-butane-1,2-diol

: 191673-60-6
2-[4-t-Butoxycarbonyl-(2 R)-(3,4-dichlorophenyl)morpholin-2-yl]ethanol t-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine

2: LiClO₄ / acetonitrile / 100 °C

3: Et₃N / CH₂Cl₂

4: 92 percent / DEAD; Ph₃P / toluene

With pyridine; lithium perchlorate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In dichloromethane; toluene; acetonitrile; 1: Tosylation / 2: Substitution / 3: Acylation / 4: Dehydration;
DOI:10.1016/S0960-894X(00)00324-3

Reference yield:

: (R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(3,4-dichloro-phenyl)-1-(2-hydroxy-ethylamino)-butan-2-ol

: 191673-60-6
2-[4-t-Butoxycarbonyl-(2 R)-(3,4-dichlorophenyl)morpholin-2-yl]ethanol t-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂

2: 92 percent / DEAD; Ph₃P / toluene

With triethylamine; triphenylphosphine; diethylazodicarboxylate; In dichloromethane; toluene; 1: Acylation / 2: Dehydration;
DOI:10.1016/S0960-894X(00)00324-3