(R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(3,4-dichloro-phenyl)-butane-1,2-diol

Base Information

Chemical Name:(R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(3,4-dichloro-phenyl)-butane-1,2-diol
CAS No.:191673-32-2
Molecular Formula:C₁₆H₂₆Cl₂O₃Si
Molecular Weight:365.372
Hs Code.:

Synonyms:(R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(3,4-dichloro-phenyl)-butane-1,2-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(3,4-dichloro-phenyl)-butane-1,2-diol

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Technology Process of (R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(3,4-dichloro-phenyl)-butane-1,2-diol

There total 6 articles about (R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(3,4-dichloro-phenyl)-butane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 191673-30-0
tert-Butyl-[3-(3,4-dichloro-phenyl)-but-3-enyloxy]-dimethyl-silane

: 191673-32-2
(R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(3,4-dichloro-phenyl)-butane-1,2-diol

Guidance literature:: With AD-mix-β; In water; tert-butyl alcohol; at 0 ℃; for 8h;
DOI:10.1016/S0957-4166(98)00336-X

Reference yield:

: 18282-59-2
4-bromo-1,2-dichlorobenzene

: 191673-32-2
(R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(3,4-dichloro-phenyl)-butane-1,2-diol

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Mg, I₂, ZnCl₂, 2.) PdCl₂(PPh₃)2 / 1.) Et₂O, 1 h, 2.) Et₂O, RT, 30 min

2: conc. H₂SO₄ / 0.5 h / Heating

3: 1.) LiAlH₄, 2.) aq. NaOH / 1.) THF, 0 deg C, 30 min, 2.) RT, 1 h

4: Et₃N, 4-dimethylaminopyridine / dimethylformamide / 2 h

5: 94 percent / AD-mix-β / 2-methyl-propan-2-ol; H2O / 8 h / 0 °C

With dmap; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; lithium aluminium tetrahydride; AD-mix-β; sulfuric acid; iodine; magnesium; triethylamine; zinc(II) chloride; In water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0957-4166(98)00336-X

Reference yield:

: 82511-02-2
((3-bromobut-3-en-1-yl)oxy)(tert-butyl)dimethylsilane

: 191673-32-2
(R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(3,4-dichloro-phenyl)-butane-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Mg, I₂, 2.) PdCl₂(PPh₃)2 / 1.) Et₂O, RT, 15 min, 2.) Et₂O, THF, RT, 3 h

2: 94 percent / AD-mix-β / 2-methyl-propan-2-ol; H2O / 8 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; AD-mix-β; iodine; magnesium; In water; tert-butyl alcohol;
DOI:10.1016/S0957-4166(98)00336-X