dibenzyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-(tert-butoxy)-3-oxopropyl]phenoxy}malonate

Base Information

Chemical Name:dibenzyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-(tert-butoxy)-3-oxopropyl]phenoxy}malonate
CAS No.:221077-13-0
Molecular Formula:C₄₁H₄₃NO₁₀
Molecular Weight:709.793
Hs Code.:

Synonyms:dibenzyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-(tert-butoxy)-3-oxopropyl]phenoxy}malonate

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Chemical Property of dibenzyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-(tert-butoxy)-3-oxopropyl]phenoxy}malonate

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Technology Process of dibenzyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-(tert-butoxy)-3-oxopropyl]phenoxy}malonate

There total 1 articles about dibenzyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-(tert-butoxy)-3-oxopropyl]phenoxy}malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 65100-24-5
dibenzyl 2-bromomalonate

: 221077-12-9
benzyl 4-{[(1S)-2-(tert-butoxy)-1-(4-hydroxybenzyl)-2-oxoethyl]amino}-4-oxobutanoate

: 221077-13-0
dibenzyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-(tert-butoxy)-3-oxopropyl]phenoxy}malonate

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃;
DOI:10.1021/jm010393s

Reference yield: 100.0%

: 221077-13-0
dibenzyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-(tert-butoxy)-3-oxopropyl]phenoxy}malonate

: 221077-14-1
(2S)-3-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}phenyl)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}propanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h;
DOI:10.1021/jm010393s

Reference yield:

: 221077-13-0
dibenzyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-(tert-butoxy)-3-oxopropyl]phenoxy}malonate

: 2-{4-[(S)-2-Butylcarbamoyl-2-(3-carboxy-propionylamino)-ethyl]-phenoxy}-malonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h

2: EDC / CH₂Cl₂ / 20 °C

3: H₂ / 10percent Pd/C / methanol / 3 h

With hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; 10percent Pd/C; In methanol; dichloromethane;
DOI:10.1021/jm010393s