(2S)-3-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}phenyl)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}propanoic acid

Base Information

• Chemical Name: (2S)-3-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}phenyl)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}propanoic acid
• CAS No.: 221077-14-1
• Molecular Formula: C₃₇H₃₅NO₁₀
• Molecular Weight: 653.686

Synonyms:(2S)-3-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}phenyl)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}propanoic acid

Chemical Property of (2S)-3-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}phenyl)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}propanoic acid

Chemical Property:

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Technology Process of (2S)-3-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}phenyl)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}propanoic acid

There total 1 articles about (2S)-3-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}phenyl)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

dibenzyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-(tert-butoxy)-3-oxopropyl]phenoxy}malonate (221077-13-0) → (2S)-3-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}phenyl)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}propanoic acid (221077-14-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 2h;

DOI:10.1021/jm010393s

Reference yield:

3-(1H-imidazol-1-yl)propan-1-amine (5036-48-6) + (2S)-3-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}phenyl)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}propanoic acid (221077-14-1) → 2-{4-[(S)-2-(3-Benzyloxycarbonyl-propionylamino)-2-(3-imidazol-1-yl-propylcarbamoyl)-ethyl]-phenoxy}-malonic acid dibenzyl ester

Guidance literature:

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;

DOI:10.1021/jm010393s

Reference yield:

1-amino-3-methylbutane (107-85-7) + (2S)-3-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}phenyl)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}propanoic acid (221077-14-1) → 2-{4-[(S)-2-(3-Benzyloxycarbonyl-propionylamino)-2-(3-methyl-butylcarbamoyl)-ethyl]-phenoxy}-malonic acid dibenzyl ester (1026709-07-8)

Guidance literature:

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1021/jm010393s

upstream raw materials:

dibenzyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-(tert-butoxy)-3-oxopropyl]phenoxy}malonate

Downstream raw materials:

2-{4-[(S)-2-(3-Benzyloxycarbonyl-propionylamino)-2-(2-piperidin-1-yl-ethylcarbamoyl)-ethyl]-phenoxy}-malonic acid dibenzyl ester

2-{4-[(S)-2-(3-Benzyloxycarbonyl-propionylamino)-2-(3-methyl-butylcarbamoyl)-ethyl]-phenoxy}-malonic acid dibenzyl ester

2-{4-[(S)-2-(3-Benzyloxycarbonyl-propionylamino)-2-(cyclohexylmethyl-carbamoyl)-ethyl]-phenoxy}-malonic acid dibenzyl ester

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