<(S)-1-Benzyl-2-<(R)-2-<2-(4-tert.-butyldimethylsilyloxy-3-methoxyphenyl)-2-oxoethyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat

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Chemical Name:<(S)-1-Benzyl-2-<(R)-2-<2-(4-tert.-butyldimethylsilyloxy-3-methoxyphenyl)-2-oxoethyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat
CAS No.:132255-73-3
Molecular Formula:C₃₃H₄₇NO₆Si
Molecular Weight:581.825
Hs Code.:

Synonyms:<(S)-1-Benzyl-2-<(R)-2-<2-(4-tert.-butyldimethylsilyloxy-3-methoxyphenyl)-2-oxoethyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat

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Chemical Property of <(S)-1-Benzyl-2-<(R)-2-<2-(4-tert.-butyldimethylsilyloxy-3-methoxyphenyl)-2-oxoethyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat

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Technology Process of <(S)-1-Benzyl-2-<(R)-2-<2-(4-tert.-butyldimethylsilyloxy-3-methoxyphenyl)-2-oxoethyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat

There total 3 articles about <(S)-1-Benzyl-2-<(R)-2-<2-(4-tert.-butyldimethylsilyloxy-3-methoxyphenyl)-2-oxoethyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132255-78-8
4-(tert.-Butyldimethylsilyloxy)-3-methoxyacetophenon

: 132255-73-3
<(S)-1-Benzyl-2-<(R)-2-<2-(4-tert.-butyldimethylsilyloxy-3-methoxyphenyl)-2-oxoethyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / Tetrabutylammoniumfluoride / tetrahydrofuran / 1) -78 deg C, 3 h, 2) to 0 deg C, 1 h, 3) 0 deg C, 2 h

2: 1) TiCl₄ / 1) CH₂Cl₂, 0 deg C, 45 min, 2) 0deg C, 16h

With tetrabutyl ammonium fluoride; titanium tetrachloride; In tetrahydrofuran;
DOI:10.1002/ardp.19903231208

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 132255-73-3
<(S)-1-Benzyl-2-<(R)-2-<2-(4-tert.-butyldimethylsilyloxy-3-methoxyphenyl)-2-oxoethyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / Imidazole / dimethylformamide / 3 h / Ambient temperature

2: 72 percent / Tetrabutylammoniumfluoride / tetrahydrofuran / 1) -78 deg C, 3 h, 2) to 0 deg C, 1 h, 3) 0 deg C, 2 h

3: 1) TiCl₄ / 1) CH₂Cl₂, 0 deg C, 45 min, 2) 0deg C, 16h

With 1H-imidazole; tetrabutyl ammonium fluoride; titanium tetrachloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/ardp.19903231208

Reference yield:

: 498-02-2
1-(3-methoxy-4-hydroxyphenyl)ethanone

: 132255-73-3
<(S)-1-Benzyl-2-<(R)-2-<2-(4-tert.-butyldimethylsilyloxy-3-methoxyphenyl)-2-oxoethyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / Imidazole / dimethylformamide / 3 h / Ambient temperature

2: 72 percent / Tetrabutylammoniumfluoride / tetrahydrofuran / 1) -78 deg C, 3 h, 2) to 0 deg C, 1 h, 3) 0 deg C, 2 h

3: 1) TiCl₄ / 1) CH₂Cl₂, 0 deg C, 45 min, 2) 0deg C, 16h

With 1H-imidazole; tetrabutyl ammonium fluoride; titanium tetrachloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/ardp.19903231208