Technology Process of 4-[3-isopropyl-4-(triisopropylsilyloxy)benzyl]-3,5-dimethylbenzaldehyde
There total 10 articles about 4-[3-isopropyl-4-(triisopropylsilyloxy)benzyl]-3,5-dimethylbenzaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
[4-(2,6-dimethyl-4-vinylbenzyl)-2-isopropylphenoxy]triisopropylsilane;
With
ozone;
In
dichloromethane;
at -78 ℃;
With
triphenylphosphine;
In
dichloromethane;
at -78 - 20 ℃;
for 0.833333h;
DOI:10.1021/jm0301181
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 72 percent / imidazole / 1,2-dichloro-ethane / Heating
2.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C
2.2: 77 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C
3.1: 100 percent / H2 / Pd/C / ethyl acetate; ethanol / 24 h / 1810.02 Torr
4.1: 99 percent / pyridine / CH2Cl2 / 4 h
5.1: LiCl; Cl2Pd(PPh3)2 / dimethylformamide / 2 h / 60 °C
6.1: O3 / CH2Cl2 / -78 °C
6.2: 86 percent / PPh3 / CH2Cl2 / 0.83 h / -78 - 20 °C
With
pyridine; 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; hydrogen; ozone; lithium chloride;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
5.1: Stille coupling;
DOI:10.1021/jm0301181
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 78 percent / K2CO3 / dimethylformamide / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C
2.2: 80 percent / tetrahydrofuran; hexane / 0.33 h / -78 °C
3.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C
3.2: 77 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C
4.1: 100 percent / H2 / Pd/C / ethyl acetate; ethanol / 24 h / 1810.02 Torr
5.1: 99 percent / pyridine / CH2Cl2 / 4 h
6.1: LiCl; Cl2Pd(PPh3)2 / dimethylformamide / 2 h / 60 °C
7.1: O3 / CH2Cl2 / -78 °C
7.2: 86 percent / PPh3 / CH2Cl2 / 0.83 h / -78 - 20 °C
With
pyridine; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; hydrogen; potassium carbonate; ozone; lithium chloride;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
6.1: Stille coupling;
DOI:10.1021/jm0301181
![[4-(2,6-dimethyl-4-vinylbenzyl)-2-isopropylphenoxy]triisopropylsilane](/Databaselist/images/loading.webp)
