2-(4-methyl cinnamoyloxy)acetophenone

Base Information

• Chemical Name: 2-(4-methyl cinnamoyloxy)acetophenone
• CAS No.: 153854-88-7
• Molecular Formula: C₁₈H₁₆O₃
• Molecular Weight: 280.323
• Mol file: 153854-88-7.mol

Synonyms:2-(4-methyl cinnamoyloxy)acetophenone

Chemical Property of 2-(4-methyl cinnamoyloxy)acetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methyl cinnamoyloxy)acetophenone

There total 4 articles about 2-(4-methyl cinnamoyloxy)acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(E)-p-methylcinnamoyl chloride (15851-89-5,13565-07-6) + o-hydroxyacetophenone (118-93-4,104809-67-8) → 2-(4-methyl cinnamoyloxy)acetophenone (153854-88-7)

Guidance literature:

In pyridine; for 0.75h; Ambient temperature;

DOI:10.1016/0031-6865(94)90040-X

Reference yield: 80.0%

trans-p-methylcinnamic acid (1866-39-3,940-61-4) + o-hydroxyacetophenone (118-93-4,104809-67-8) → 2-(4-methyl cinnamoyloxy)acetophenone (153854-88-7)

Guidance literature:

With pyridine; trichlorophosphate; at 60 ℃; for 3h;

DOI:10.1002/jhet.5570350140

Reference yield:

trans-p-methylcinnamic acid (1866-39-3,940-61-4) → 2-(4-methyl cinnamoyloxy)acetophenone (153854-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / SOCl₂ / cyclohexane / 3 h / Heating

2: 97 percent / pyridine / 0.75 h / Ambient temperature

With thionyl chloride; In pyridine; cyclohexane;

DOI:10.1016/0031-6865(94)90040-X

upstream raw materials:

(E)-p-methylcinnamoyl chloride

o-hydroxyacetophenone

trans-p-methylcinnamic acid

4-methylcinnamic acid

Downstream raw materials:

(E)-2-[2-(4-methylphenyl)vinyl]-4H-chromen-4-one

(2Z,4E)-3-Hydroxy-1-(2-hydroxy-phenyl)-5-p-tolyl-penta-2,4-dien-1-one

ω-para methyl cinnamoyl 2-hydroxyacetophenone