5-(3,5-dimethylisoxazol-4-yl)-1-(4-methoxyphenyl)-3-propyl-1H-pyrazole-4-carbonitrile

Base Information

Chemical Name:5-(3,5-dimethylisoxazol-4-yl)-1-(4-methoxyphenyl)-3-propyl-1H-pyrazole-4-carbonitrile
CAS No.:1290138-36-1
Molecular Formula:C₁₉H₂₀N₄O₂
Molecular Weight:336.393
Hs Code.:

Synonyms:5-(3,5-dimethylisoxazol-4-yl)-1-(4-methoxyphenyl)-3-propyl-1H-pyrazole-4-carbonitrile

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Chemical Property of 5-(3,5-dimethylisoxazol-4-yl)-1-(4-methoxyphenyl)-3-propyl-1H-pyrazole-4-carbonitrile

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Technology Process of 5-(3,5-dimethylisoxazol-4-yl)-1-(4-methoxyphenyl)-3-propyl-1H-pyrazole-4-carbonitrile

There total 8 articles about 5-(3,5-dimethylisoxazol-4-yl)-1-(4-methoxyphenyl)-3-propyl-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-5-(3,5-dimethylisoxazol-4-yl)-1-(4-methoxyphenyl)-3-propyl-1H-pyrazole-4-carbaldehyde oxime

: 1290138-36-1
5-(3,5-dimethylisoxazol-4-yl)-1-(4-methoxyphenyl)-3-propyl-1H-pyrazole-4-carbonitrile

Guidance literature:: With acetic anhydride; at 140 ℃; for 0.666667h; microwave irradiation;

Reference yield:

: 1290138-35-0
5-(3,5-dimethylisoxazol-4-yl)-1-(4-methoxyphenyl)-3-propyl-1H-pyrazole-4-carbaldehyde oxime

: 1290138-36-1
5-(3,5-dimethylisoxazol-4-yl)-1-(4-methoxyphenyl)-3-propyl-1H-pyrazole-4-carbonitrile

Guidance literature:: With acetic anhydride; at 150 ℃; for 0.666667h; Microwave irradiation;

Reference yield:

: 3471-32-7
4-Methoxyphenylhydrazine

: 1290138-36-1
5-(3,5-dimethylisoxazol-4-yl)-1-(4-methoxyphenyl)-3-propyl-1H-pyrazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; triethylamine / 30 h / 120 °C

2.1: phosphorus tribromide / acetonitrile / 0.67 h / 150 °C / Microwave irradiation

3.1: potassium carbonate; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

4.1: trichlorophosphate / toluene / 0.08 h / 0 °C

4.2: 0.33 h / 150 °C / Microwave irradiation

5.1: hydroxylamine hydrochloride; pyridine / ethanol / 0.17 h / 150 °C / Microwave irradiation

6.1: acetic anhydride / 0.67 h / 150 °C / Microwave irradiation

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; acetic anhydride; phosphorus tribromide; potassium carbonate; acetic acid; triethylamine; sodium iodide; trichlorophosphate; In 1,4-dioxane; ethanol; water; toluene; acetonitrile;