diethyl 2-acetoxy-2-[6-chloro-2-(3-fluorobenzoyl)-1H-indol-3-yl]malonate

Base Information

Chemical Name:diethyl 2-acetoxy-2-[6-chloro-2-(3-fluorobenzoyl)-1H-indol-3-yl]malonate
CAS No.:231295-27-5
Molecular Formula:C₂₄H₂₁ClFNO₇
Molecular Weight:489.885
Hs Code.:

Synonyms:diethyl 2-acetoxy-2-[6-chloro-2-(3-fluorobenzoyl)-1H-indol-3-yl]malonate

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Chemical Property of diethyl 2-acetoxy-2-[6-chloro-2-(3-fluorobenzoyl)-1H-indol-3-yl]malonate

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Technology Process of diethyl 2-acetoxy-2-[6-chloro-2-(3-fluorobenzoyl)-1H-indol-3-yl]malonate

There total 8 articles about diethyl 2-acetoxy-2-[6-chloro-2-(3-fluorobenzoyl)-1H-indol-3-yl]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 231295-26-4
(6-chloro-1H-indol-2-yl)(3-fluorophenyl)methanone

: 127-09-3
sodium acetate

: 105-53-3
diethyl malonate

: 231295-27-5
diethyl 2-acetoxy-2-[6-chloro-2-(3-fluorobenzoyl)-1H-indol-3-yl]malonate

Guidance literature:: With manganese(III) triacetate dihydrate; acetic acid; at 20 - 80 ℃; for 5.58333h; Inert atmosphere;
DOI:10.3109/14756366.2013.864650

Reference yield:

: 231295-26-4
(6-chloro-1H-indol-2-yl)(3-fluorophenyl)methanone

: 231295-27-5
diethyl 2-acetoxy-2-[6-chloro-2-(3-fluorobenzoyl)-1H-indol-3-yl]malonate

Guidance literature:

Reference yield:

: 6-chloro-1H-indole-2-carbonyl chloride

: 231295-27-5
diethyl 2-acetoxy-2-[6-chloro-2-(3-fluorobenzoyl)-1H-indol-3-yl]malonate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

2: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

3: acetic acid; manganese(III) triacetate dihydrate / 5.58 h / 20 - 80 °C / Inert atmosphere

With pyridine; n-butyllithium; manganese(III) triacetate dihydrate; acetic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.3109/14756366.2013.864650