DIMETHYLPHENYLSILYLACETIC ACID

Base Information

• Chemical Name: DIMETHYLPHENYLSILYLACETIC ACID
• CAS No.: 17887-62-6
• Molecular Formula: C10H14 O2 Si
• Molecular Weight: 194.3
• Hs Code.: 2931900090
• Mol file: 17887-62-6.mol

Synonyms:Aceticacid, (dimethylphenylsilyl)- (8CI,9CI); SDK 23

Chemical Property of DIMETHYLPHENYLSILYLACETIC ACID

Chemical Property:

• Vapor Pressure: 0.000571mmHg at 25°C
• Refractive Index: 1.509
• Boiling Point: 298.4°C at 760 mmHg
• PKA: pK1:5.27 (25°C)
• Flash Point: 134.2°C
• PSA: 37.30000
• Density: 1.04g/cm³
• LogP: 1.68660

Purity/Quality:

97% ^*data from raw suppliers

DIMETHYLPHENYLSILYLACETIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIMETHYLPHENYLSILYLACETIC ACID

There total 8 articles about DIMETHYLPHENYLSILYLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

trimethylsilyl acetate (2754-27-0) + phenyldimethylsilyl chloride (768-33-2) → (dimethylphenylsilyl)acetic acid (17887-62-6)

Guidance literature:

trimethylsilyl acetate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h;

phenyldimethylsilyl chloride; In tetrahydrofuran; at -78 ℃; for 2h; Further stages.;

DOI:10.1016/j.tetlet.2008.03.050

Reference yield: 69.0%

[(dimethylphenylsilyl)methyl]magnesium chloride (107735-20-6) → (dimethylphenylsilyl)acetic acid (17887-62-6)

Guidance literature:

With CO₂; In not given; (CH3)2(C6H5)SiCH2MgBr and solid CO2; hydrolysis;;

DOI:10.1021/ja01172a521

Reference yield:

methylammonium carbonate (15719-64-9,15719-76-3,97762-63-5) → (dimethylphenylsilyl)acetic acid (17887-62-6)

Guidance literature:

With diethyl ether;

DOI:10.1021/ja01172a521

upstream raw materials:

carbon dioxide

(bromomethyl)dimethylphenylsilane

(dimethylphenylsilyl)ketene

methylammonium carbonate

Downstream raw materials:

1,2-bis[dimethyl(phenyl)silyl]ethane

(dimethylphenylsilyl)ketene

2-(dimethyl-phenyl-silanyl)-3-phenyl-thiopropionic acid S-phenyl ester

(S)-2-(dimethyl(phenyl)silyl)-3-phenylpropan-1-ol

Refernces

• 1、 Shtelman, Alex V.,Becker, James Y.. "Electrochemical synthesis of 1,2-disilylethanes from α-silylacetic acids". scheme or table. p. 4710 - 4714. Retrieved 2011/07/08.
• 2、 Liu, Ronghau,Marra, Romeo M.,Tidwell, Thomas T.. "Phenyldimethylsilyl-substituted ketenes and bisketenes". . p. 6227 - 6232. Retrieved 2007/10/03.