4-diphenylphosphinoyl-5-hydroxy-4-methyl-5-p-methoxyphenylpentan-2-one ethylene acetal

Base Information

• Chemical Name: 4-diphenylphosphinoyl-5-hydroxy-4-methyl-5-p-methoxyphenylpentan-2-one ethylene acetal
• CAS No.: 344743-32-4
• Molecular Formula: C₂₇H₃₁O₅P
• Molecular Weight: 466.514
• Mol file: 344743-32-4.mol

Synonyms:4-diphenylphosphinoyl-5-hydroxy-4-methyl-5-p-methoxyphenylpentan-2-one ethylene acetal

Chemical Property of 4-diphenylphosphinoyl-5-hydroxy-4-methyl-5-p-methoxyphenylpentan-2-one ethylene acetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-diphenylphosphinoyl-5-hydroxy-4-methyl-5-p-methoxyphenylpentan-2-one ethylene acetal

There total 6 articles about 4-diphenylphosphinoyl-5-hydroxy-4-methyl-5-p-methoxyphenylpentan-2-one ethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-diphenylphosphinoyl-4-hydroxy-4-methyl-1-phenylpentan-1-one ethylene acetal (69803-70-9) → 4-diphenylphosphinoyl-5-hydroxy-4-methyl-5-p-methoxyphenylpentan-2-one ethylene acetal (344743-32-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 24 percent / NaH / tetrahydrofuran / 20 h / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C

With n-butyllithium; sodium hydride; In tetrahydrofuran;

Reference yield:

2-diphenylphosphinoylpentan-4-one (69803-58-3) → 4-diphenylphosphinoyl-5-hydroxy-4-methyl-5-p-methoxyphenylpentan-2-one ethylene acetal (344743-32-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / TsOH / benzene / 24 h / Heating

2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C

With n-butyllithium; toluene-4-sulfonic acid; In benzene;

Reference yield:

(β-benzoylethyl)diphenylphosphine oxide (69803-60-7) → 4-diphenylphosphinoyl-5-hydroxy-4-methyl-5-p-methoxyphenylpentan-2-one ethylene acetal (344743-32-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 91 percent / TsOH / benzene / Heating

2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 5 min

3: 24 percent / NaH / tetrahydrofuran / 20 h / Ambient temperature

4: 1.) n-BuLi / 1.) THF, hexane, 0 deg C

With n-butyllithium; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;

upstream raw materials:

4-methoxy-benzaldehyde

4-diphenylphosphinoylpentan-2-one ethylene acetal

3-diphenylphosphinoyl-4-hydroxy-4-methyl-1-phenylpentan-1-one ethylene acetal

2-diphenylphosphinoylpentan-4-one

Downstream raw materials:

4-methoxy-benzaldehyde

5-p-methoxyphenyl-4-methylpent-4-en-2-one ethylene acetal

4-diphenylphosphinoylpentan-2-one ethylene acetal