(S)-N-[3-[3-fluoro-4-N-methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]acetamide

Base Information

Chemical Name:(S)-N-[3-[3-fluoro-4-N-methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]acetamide
CAS No.:324788-63-8
Molecular Formula:C₁₃H₁₆FN₃O₃
Molecular Weight:281.287
Hs Code.:

Synonyms:(S)-N-[3-[3-fluoro-4-N-methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]acetamide

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Chemical Property of (S)-N-[3-[3-fluoro-4-N-methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]acetamide

Chemical Property:

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Technology Process of (S)-N-[3-[3-fluoro-4-N-methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]acetamide

There total 11 articles about (S)-N-[3-[3-fluoro-4-N-methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]acetamide

: 324788-63-8
(S)-N-[3-[3-fluoro-4-N-methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]acetamide

Guidance literature:: (S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]acetamide; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

With sodium hydrogencarbonate; In dichloromethane; for 0.25h;

Reference yield:

: 5-(S)-azidomethyl-3-[4'-(tert-butoxycarbonyl)amino-3'-fluorophenyl]oxazolidine-2-one

: 74-88-4
methyl iodide

: 324788-63-8
(S)-N-[3-[3-fluoro-4-N-methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]acetamide

: 5-(S)-azidomethyl-3-[4'-(tert-butoxycarbonyl)methylamino-3'-fluorophenyl]oxazolidine-2-one

Guidance literature:: With lithium hydride; In diethyl ether; water; dimethyl sulfoxide;

Reference yield:

: tert-butyl (4-amino-2-fluorophenyl)(methyl)carbamate

: 324788-63-8
(S)-N-[3-[3-fluoro-4-N-methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / water; acetone / 14 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -70 °C

2.2: 14 h / -70 - 20 °C

3.1: triethylamine / dichloromethane / 6 h / 20 °C

4.1: sodium azide / DMF (N,N-dimethyl-formamide) / 6 h / 20 - 80 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C / 2585.81 Torr

6.1: pyridine / chloroform / 12 h / 0 - 20 °C

7.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

7.2: 0.25 h

With pyridine; n-butyllithium; sodium azide; hydrogen; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); hexane; dichloromethane; chloroform; water; acetone;