(1R,1'R)- ethane-1,2-diylbis((2-isopropoxyphenyl)(phenyl)phosphine borane)

Base Information

• Chemical Name: (1R,1'R)- ethane-1,2-diylbis((2-isopropoxyphenyl)(phenyl)phosphine borane)
• CAS No.: 917029-17-5
• Molecular Formula: C₃₂H₄₂B₂O₂P₂
• Molecular Weight: 542.254
• Mol file: 917029-17-5.mol

Synonyms:(1R,1'R)- ethane-1,2-diylbis((2-isopropoxyphenyl)(phenyl)phosphine borane)

Chemical Property of (1R,1'R)- ethane-1,2-diylbis((2-isopropoxyphenyl)(phenyl)phosphine borane)

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (1R,1'R)- ethane-1,2-diylbis((2-isopropoxyphenyl)(phenyl)phosphine borane)

There total 6 articles about (1R,1'R)- ethane-1,2-diylbis((2-isopropoxyphenyl)(phenyl)phosphine borane) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-iodo-propane (75-30-9) + (RP,RP)-1,2-bis[(o-hydroxyphenyl)(phenyl)phosphino-P-borane]ethane (1316041-04-9,917029-15-3) → (1R,1'R)- ethane-1,2-diylbis((2-isopropoxyphenyl)(phenyl)phosphine borane) (917029-17-5)

Guidance literature:

With potassium carbonate; In acetone; Inert atmosphere; Reflux;

DOI:10.1002/adsc.200900621

Reference yield:

(RP,RP)-1,2-bis[(o-hydroxyphenyl)(phenyl)phosphino-P-borane]ethane (1316041-04-9,917029-15-3) → (1R,1'R)- ethane-1,2-diylbis((2-isopropoxyphenyl)(phenyl)phosphine borane) (917029-17-5)

Guidance literature:

With K₂CO₃; In acetone; mixt. of B compd., K2CO3 and i-Pr iodide, bromide or tosylate in acetonestirred at room temp. or refluxed; concd.; filtered through silica gel pad; eluted with CH2Cl2; recrystd. from hexane-CH2Cl2;

DOI:10.1039/c1ob05364g

Reference yield:

borane-THF (14044-65-6) + (1R,1'R)-ethane-1,2-diylbis((2-isopropoxyphenyl)(phenyl)phosphine oxide) → (1R,1'R)- ethane-1,2-diylbis((2-isopropoxyphenyl)(phenyl)phosphine borane) (917029-17-5) + C32H42B2O2P2

Guidance literature:

(1R,1'R)-ethane-1,2-diylbis((2-isopropoxyphenyl)(phenyl)phosphine oxide); With methyl trifluoromethanesulfonate; In 1,2-dimethoxyethane; at 20 ℃; for 2h; Inert atmosphere;

With lithium aluminium tetrahydride; In tetrahydrofuran; 1,2-dimethoxyethane; at -70 ℃; for 4h; Inert atmosphere;

borane-THF; In tetrahydrofuran; 1,2-dimethoxyethane; Overall yield = 76 percent; Overall yield = 207.3 mg; enantioselective reaction; Inert atmosphere;

DOI:10.1021/jacs.9b11938

upstream raw materials:

2-iodo-propane

(R_P,R_P)-1,2-bis[(o-hydroxyphenyl)(phenyl)phosphino-P-borane]ethane

methyl(phenyl)phosphineoxide

1-bromo-2-isopropoxybenzene

Downstream raw materials:

(Rp,Rp)-1,2-bis[(2-isopropoxyphenyl)(phenyl)phosphino]ethane