Pyrimidine, 4-(2-furanyl)- (9CI)

Base Information

• Chemical Name: Pyrimidine, 4-(2-furanyl)- (9CI)
• CAS No.: 17749-82-5
• Molecular Formula: C8H6 N2 O
• Molecular Weight: 146.14604
• Mol file: 17749-82-5.mol

Synonyms:Pyrimidine,4-(2-furyl)- (6CI,8CI); 4-(2-furanyl)pyrimidine

Chemical Property of Pyrimidine, 4-(2-furanyl)- (9CI)

Chemical Property:

• PSA: 38.92000
• LogP: 1.73660

Purity/Quality:

4-(2-FURANYL)-PYRIMIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrimidine, 4-(2-furanyl)- (9CI)

There total 9 articles about Pyrimidine, 4-(2-furanyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1,3,5-Triazine (290-87-9) + 1-(2-furyl)-1-ethanone (1192-62-7,80145-44-4) → 4-(furan-2-yl)pyrimidine (17749-82-5)

Guidance literature:

With morpholine; triethylamine; In methanol; at 90 ℃; for 72h; regioselective reaction;

DOI:10.1039/c5ra16995j

Reference yield: 86.0%

1-(2-furyl)-1-ethanone (1192-62-7,80145-44-4) + triformylaminomethane (6966-73-0) → 4-(furan-2-yl)pyrimidine (17749-82-5)

Guidance literature:

With toluene-4-sulfonic acid;

DOI:10.2174/13862073113169990050

Reference yield: 60.0%

1-(2-furyl)-1-ethanone (1192-62-7,80145-44-4) + 3-methyl-5-nitro-4(3H)-pyrimidinone (17758-33-7) → 4-(furan-2-yl)pyrimidine (17749-82-5) + 6-(2-furyl)-3-nitro-2-pyridine

Guidance literature:

With ammonium acetate; In methanol; for 48h; Heating;

DOI:10.1055/s-2004-829195

upstream raw materials:

furan

PYRIMIDINE

2-lithiofuran

diethyl ether

Downstream raw materials:

C₂₁H₁₅BrN₂O₄

C₂₂H₁₅F₃N₂O₄

C₂₂H₁₅F₃N₂O₄

Refernces

• 1、 Yang, Gongming,Jia, Qianfa,Chen, Lei,Du, Zhiyun,Wang, Jian. "Direct access to pyrimidines through organocatalytic inverse-electron-demand Diels-Alder reaction of ketones with 1,3,5-triazine". . p. 76759 - 76763. Retrieved 2015/09/28.
• 2、 Tyagarajan, Sriram,Chakravarty, Prasun K.. "Synthesis of pyrimidines from ketones using microwave irradiation". . p. 7889 - 7891. Retrieved 2007/10/03.