N-CARBOBENZOXY-L-LEUCYL-L-ALANINE BENZYL ESTER

Base Information

• Chemical Name: N-CARBOBENZOXY-L-LEUCYL-L-ALANINE BENZYL ESTER
• CAS No.: 17664-94-7
• Molecular Formula: C24H30 N2 O5
• Molecular Weight: 426.513
• Mol file: 17664-94-7.mol

Synonyms:Alanine,N-(N-carboxy-L-leucyl)-, dibenzyl ester, L- (8CI)

Chemical Property of N-CARBOBENZOXY-L-LEUCYL-L-ALANINE BENZYL ESTER

Chemical Property:

• PSA: 93.73000
• LogP: 4.35740

Purity/Quality:

97% ^*data from raw suppliers

N-CARBOBENZOXY-L-LEUCYL-L-ALANINE BENZYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-CARBOBENZOXY-L-LEUCYL-L-ALANINE BENZYL ESTER

There total 3 articles about N-CARBOBENZOXY-L-LEUCYL-L-ALANINE BENZYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

Z-Leu-OH (2018-66-8) + L-alanine benzyl ester hydrochloride (5557-81-3,5557-83-5,34404-37-0) → N-(benzyloxycarbonyl)-L-leucyl-L-alanine phenylmethyl ester (17664-94-7)

Guidance literature:

With dmap; triphenylphosphine; iodosodilactone; In chloroform; at 60 ℃; for 6h;

DOI:10.1021/ol301085v

Reference yield:

Z-Leu-OH (2018-66-8) + L-alanine benzyl ester p-toluenesulfonate (42854-62-6) → N-(benzyloxycarbonyl)-L-leucyl-L-alanine phenylmethyl ester (17664-94-7)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide;

DOI:10.1016/j.tet.2004.11.058

Reference yield:

L-alanine benzyl ester p-toluenesulfonate (42854-62-6) + N-(benzyloxycarbonyl)leucine dicyclohexylamine salt (53363-87-4) → N-(benzyloxycarbonyl)-L-leucyl-L-alanine phenylmethyl ester (17664-94-7)

Guidance literature:

With 4-methyl-morpholine; chloroformic acid ethyl ester; Yield given. Multistep reaction; 1.) THF, -15 deg C, 5 min, 2.) CH₂Cl₂, -15 deg C, 4 h; room temperature, overnight;

upstream raw materials:

L-alanine benzyl ester p-toluenesulfonate

N-(benzyloxycarbonyl)leucine dicyclohexylamine salt

Z-Leu-OH

L-alanine benzyl ester hydrochloride

Downstream raw materials:

Leu-Ala

H-Leu-Ala-OH