{4-[(S)-2,5-Dioxo-2-(4-phenyl-butyl)-2λ⁵-[1,3,2]dioxaphospholan-4-yl]-butyl}-carbamic acid benzyl ester

Base Information

• Chemical Name: {4-[(S)-2,5-Dioxo-2-(4-phenyl-butyl)-2λ⁵-[1,3,2]dioxaphospholan-4-yl]-butyl}-carbamic acid benzyl ester
• CAS No.: 126187-84-6
• Molecular Formula: C₂₄H₃₀NO₆P
• Molecular Weight: 459.479

Synonyms:{4-[(S)-2,5-Dioxo-2-(4-phenyl-butyl)-2λ⁵-[1,3,2]dioxaphospholan-4-yl]-butyl}-carbamic acid benzyl ester

Chemical Property of {4-[(S)-2,5-Dioxo-2-(4-phenyl-butyl)-2λ⁵-[1,3,2]dioxaphospholan-4-yl]-butyl}-carbamic acid benzyl ester

Chemical Property:

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Technology Process of {4-[(S)-2,5-Dioxo-2-(4-phenyl-butyl)-2λ⁵-[1,3,2]dioxaphospholan-4-yl]-butyl}-carbamic acid benzyl ester

There total 10 articles about {4-[(S)-2,5-Dioxo-2-(4-phenyl-butyl)-2λ⁵-[1,3,2]dioxaphospholan-4-yl]-butyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-<oxy>-6-<<(phenylmethoxy)carbonyl>amino>hexanoic acid (107492-16-0) → {4-[(S)-2,5-Dioxo-2-(4-phenyl-butyl)-2λ5-[1,3,2]dioxaphospholan-4-yl]-butyl}-carbamic acid benzyl ester (126187-84-6)

Guidance literature:

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/jm00167a028

Reference yield:

(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid (59221-35-1) + 4-phenylbutylphosphonyl dichloride (111223-20-2) → {4-[(S)-2,5-Dioxo-2-(4-phenyl-butyl)-2λ5-[1,3,2]dioxaphospholan-4-yl]-butyl}-carbamic acid benzyl ester (126187-84-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -78 - 20 ℃; for 6h;

DOI:10.1016/S0040-4039(00)85232-6

Reference yield:

4-phenylbutylphosphonyl dichloride (111223-20-2) + (R)-6-Benzyloxycarbonylamino-2-hydroxy-hexanoic acid (109545-60-0) → {4-[(R)-2,5-Dioxo-2-(4-phenyl-butyl)-2λ5-[1,3,2]dioxaphospholan-4-yl]-butyl}-carbamic acid benzyl ester (111223-21-3,111320-09-3,126187-84-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -78 - 20 ℃; for 6h;

DOI:10.1016/S0040-4039(00)85232-6

upstream raw materials:

(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid

4-phenylbutylphosphonyl dichloride

(S)-2-<oxy>-6-<<(phenylmethoxy)carbonyl>amino>hexanoic acid

4-phenyl-butyl phosphonic acid

Downstream raw materials:

1-[(S)-6-[[(phenylmethoxy)carbonyl]amino]-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L-proline

ceronapril

(S)-1-{(R)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-pyrrolidine-2-carboxylic acid

(S)-1-{(R)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-pyrrolidine-2-carboxylic acid benzyl ester

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