4-phenylbutylphosphonyl dichloride

Base Information

• Chemical Name: 4-phenylbutylphosphonyl dichloride
• CAS No.: 111223-20-2
• Molecular Formula: C₁₀H₁₃Cl₂OP
• Molecular Weight: 251.092

Synonyms:4-phenylbutylphosphonyl dichloride

Chemical Property of 4-phenylbutylphosphonyl dichloride

Chemical Property:

Purity/Quality:

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Technology Process of 4-phenylbutylphosphonyl dichloride

There total 1 articles about 4-phenylbutylphosphonyl dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-phenyl-butyl phosphonic acid (46348-61-2) → 4-phenylbutylphosphonyl dichloride (111223-20-2)

Guidance literature:

With phosphorus pentachloride;

DOI:10.1016/S0040-4039(00)85232-6

Reference yield: 82.0%

1-Adamantanamine (768-94-5) + 4-phenylbutylphosphonyl dichloride (111223-20-2) + pyrrolidine-2-carboxylic acid benzyl ester (80089-25-4) + isobutyric Acid (79-31-2) → 1-[2,2-Dimethyl-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxoethyl]-L-proline benzyl ester (111223-30-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; ethyl acetate;

Reference yield:

1-Adamantanamine (768-94-5) + 4-phenylbutylphosphonyl dichloride (111223-20-2) + (S)-6-(tert-butyloxycarbonylamino)-2-hydroxyhexanoic acid (111223-31-5) + pyrrolidine-2-carboxylic acid benzyl ester (80089-25-4) → (S)-1-[6-t-Butoxycarbonylamino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L-proline benzyl ester

Guidance literature:

With triethylamine; In tetrahydrofuran; hexane; ethyl acetate;

upstream raw materials:

4-phenyl-butyl phosphonic acid

Downstream raw materials:

{4-[(S)-2,5-Dioxo-2-(4-phenyl-butyl)-2λ⁵-[1,3,2]dioxaphospholan-4-yl]-butyl}-carbamic acid benzyl ester

{4-[(R)-2,5-Dioxo-2-(4-phenyl-butyl)-2λ⁵-[1,3,2]dioxaphospholan-4-yl]-butyl}-carbamic acid benzyl ester

Cyclohexyl-phenylbutylphosphonochloridat

ceronapril

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