4-<2-(2-ethoxy-2-oxoethoxy)phenyl>-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide

Base Information

Chemical Name:4-<2-(2-ethoxy-2-oxoethoxy)phenyl>-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide
CAS No.:85891-87-8
Molecular Formula:C₂₁H₂₆NO₅*I
Molecular Weight:499.346
Hs Code.:

Synonyms:4-<2-(2-ethoxy-2-oxoethoxy)phenyl>-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide

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Chemical Property of 4-<2-(2-ethoxy-2-oxoethoxy)phenyl>-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide

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Technology Process of 4-<2-(2-ethoxy-2-oxoethoxy)phenyl>-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide

There total 11 articles about 4-<2-(2-ethoxy-2-oxoethoxy)phenyl>-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 87307-94-6
4-(2-hydroxyphenyl)-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide

: 105-36-2
ethyl bromoacetate

: 85891-87-8
4-<2-(2-ethoxy-2-oxoethoxy)phenyl>-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 1h;
DOI:10.1021/jo00172a032

Reference yield:

: 31165-67-0
2'-benzyloxyacetophenone

: 85891-87-8
4-<2-(2-ethoxy-2-oxoethoxy)phenyl>-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide

Guidance literature:: Multi-step reaction with 8 steps

1: 2. NH₄Cl / 1.) ether, reflux, 5 h, 2.) water

2: 94 percent / hydroquinone / 0.5 h / 200 °C

3: 2.) NH₄OAc / 1.) 1,2-dichloroethane, reflux, 3 h, 2.) HAc, H₂O, 100 deg C, 1 h

4: 84 percent / pyridine, piperidine / 3 h / 100 °C

5: 91 percent / H₂ / Pd/C / ethanol / 10 h / 760 Torr

6: 95 percent / H₂, 1.02 M HCl / Pd/C / ethanol / 31 h

7: 100 percent / dimethylformamide / 1 h / 25 °C

8: 98 percent / K₂CO₃ / dimethylformamide / 1 h / 25 °C

With piperidine; pyridine; hydrogenchloride; ammonium acetate; hydrogen; potassium carbonate; ammonium chloride; hydroquinone; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00172a032

Reference yield:

: 118-93-4,104809-67-8
o-hydroxyacetophenone

: 85891-87-8
4-<2-(2-ethoxy-2-oxoethoxy)phenyl>-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide

Guidance literature:: Multi-step reaction with 9 steps

1: 93 percent / K₂CO₃, NaI / acetone / 43 h / Heating

2: 2. NH₄Cl / 1.) ether, reflux, 5 h, 2.) water

3: 94 percent / hydroquinone / 0.5 h / 200 °C

4: 2.) NH₄OAc / 1.) 1,2-dichloroethane, reflux, 3 h, 2.) HAc, H₂O, 100 deg C, 1 h

5: 84 percent / pyridine, piperidine / 3 h / 100 °C

6: 91 percent / H₂ / Pd/C / ethanol / 10 h / 760 Torr

7: 95 percent / H₂, 1.02 M HCl / Pd/C / ethanol / 31 h

8: 100 percent / dimethylformamide / 1 h / 25 °C

9: 98 percent / K₂CO₃ / dimethylformamide / 1 h / 25 °C

With piperidine; pyridine; hydrogenchloride; ammonium acetate; hydrogen; potassium carbonate; ammonium chloride; hydroquinone; sodium iodide; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00172a032