Phosphoric acid (3aR,4R,6R,6aR)-6-(6-amino-8-bromo-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-hydroxy-phenyl ester

Base Information

Chemical Name:Phosphoric acid (3aR,4R,6R,6aR)-6-(6-amino-8-bromo-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-hydroxy-phenyl ester
CAS No.:176747-04-9
Molecular Formula:C₁₉H₂₁BrN₅O₈P
Molecular Weight:558.282
Hs Code.:

Phosphoric acid (3aR,4R,6R,6aR)-6-(6-amino-8-bromo-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-hydroxy-phenyl ester

Synonyms:Phosphoric acid (3aR,4R,6R,6aR)-6-(6-amino-8-bromo-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-hydroxy-phenyl ester

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Chemical Property of Phosphoric acid (3aR,4R,6R,6aR)-6-(6-amino-8-bromo-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-hydroxy-phenyl ester

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Technology Process of Phosphoric acid (3aR,4R,6R,6aR)-6-(6-amino-8-bromo-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-hydroxy-phenyl ester

There total 2 articles about Phosphoric acid (3aR,4R,6R,6aR)-6-(6-amino-8-bromo-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-hydroxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1499-17-8
o-phenylene chlorophosphate

: 13089-45-7
8-bromo-2',3'-O-isopropylene adenosine

: 176747-04-9
Phosphoric acid (3aR,4R,6R,6aR)-6-(6-amino-8-bromo-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-hydroxy-phenyl ester

Guidance literature:: With 2,6-dimethylpyridine; In 1,4-dioxane; for 3h; Ambient temperature;
DOI:10.1021/ja953937m

Reference yield:

: 2946-39-6
8-bromoadenosine

: 176747-04-9
Phosphoric acid (3aR,4R,6R,6aR)-6-(6-amino-8-bromo-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-hydroxy-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / p-TsOH / Ambient temperature

2: 73 percent / 2,6-lutidine / dioxane / 3 h / Ambient temperature

With 2,6-dimethylpyridine; toluene-4-sulfonic acid; In 1,4-dioxane;
DOI:10.1021/ja953937m