1499-17-8

Usage

Uses

Reactant for preparation of: Uridine diphosphate-glucose derivatives as potential chain terminators of β-glucan biosynthesis with antifungal activityVinyloxy phosphorus monomersPhosphorylation agent

Purification Methods

After distilling it in a vacuum, it sets to a colourless solid. It is soluble in pet ether, *benzene and slightly soluble in Et2O. [Khwaja et al. J Chem Soc (C) 2092 1970, Anschütz & Broeker Justus Liebigs Ann Chem 454 109 1927, Beilstein 6 IV 5602.]

InChI:InChI=1/C6H4ClO3P/c7-11(8)9-5-3-1-2-4-6(5)10-11/h1-4H

Upstream product

• 120-80-9 benzene-1,2-diol 
• 2007-97-8 trichloro(o-phenylenedioxy)phosphorane 
• 67-63-0 isopropyl alcohol 
• 100-51-6 benzyl alcohol 
• 108-93-0 cyclohexanol 
• 71-36-3 butan-1-ol 
• 111-27-3 hexan-1-ol 
• 106-89-8 epichlorohydrin 
• 101519-12-4 sodiumtris(benzene-1,2 diolato)silicate 
• 10025-87-3 trichlorophosphate 
• 144-62-7 oxalic acid 
• 71-43-2 benzene 
• 17166-43-7 dimethyl (3-methylbuta-1,2-dien-1-yl)phosphonate 
• 3201-84-1 3-methyl-1,2-butadienephosphonic acid diethyl ester 

Downstream Products

• 141793-24-0 dibutylphosphinic acid 2-hydroxyphenyl ester 
• 64583-50-2 2-(2-Oxo-2λ⁵-benzo[1,3,2]dioxaphosphol-2-yloxy)-2-phenyl-ethanol 
• 64583-51-3 2-(2-Oxo-2λ⁵-benzo[1,3,2]dioxaphosphol-2-yloxy)-1-phenyl-ethanol 
• 118164-62-8 C₁₅H₁₁O₆P 
• 93593-71-6 2-[2-(2-Trimethylsilanyloxy-ethoxy)-ethoxy]-benzo[1,3,2]dioxaphosphole 2-oxide 
• 53919-70-3 Acetic acid (3S,4R,5R,6S)-4,5-diacetoxy-2-[hydroxy-(2-hydroxy-phenoxy)-phosphoryloxy]-6-methyl-tetrahydro-pyran-3-yl ester 
• 60823-55-4 diphenylphosphinic acid 2-hydroxyphenyl ester 
• 141793-23-9 Di-thiophen-2-yl-phosphinic acid 2-hydroxy-phenyl ester 
• 3005-87-6 Z-Gly-Gly-OEt 
• 51355-59-0 2-Anilino-benzodioxaphosphol-2-oxid 
• 76690-85-2 Dicyclohexyl-(2-oxo-2λ⁵-benzo[1,3,2]dioxaphosphol-2-yl)-amine 
• 141793-21-7 Bis-(4-methoxy-phenyl)-phosphinic acid 2-hydroxy-phenyl ester 
• 141793-20-6 Di-naphthalen-1-yl-phosphinic acid 2-hydroxy-phenyl ester 
• 122954-50-1 O-(2-hydroxyphenyl)-N'-(m-trifluormethylphenyl)hydrazidophosphate 

Relevant academic research and scientific papers

Synthesis and anticholinesterase activity of some benzo-1,3,2-dioxaphospholene, oxazaphospholine and diazaphospholine 2-ones containing 2-amino acid substitution

Synthesis of the titled compounds has been described. 1H NMR, IR band frequencies and MS fragmentation and rearrangement peaks were analyzed and discussed in detail. Studying the inhibitory effect of these compounds on acetylcholinesterase (AChE) showed that dioxaphospholenes were stronger inhibitors than oxazaphospholines and diazaphospholines. This was explained by increasing the number of nitrogen atoms around the phosphorus atom in the later two series, which reduces the electrophilic character of the phosphorus atom by the overlapping between the dπ - pπ orbitals of the phosphorus and the neighboring nitrogen atoms, and hence reducing the electrophilic attack of the phosphorus atom on a nucleophilic center at the esteratic site of the enzyme. Steric factor of the amino acid moiety showed stronger effect than the electronic factor on the inhibition activity, the observed order was glycine > glutamic > methaionine > phenylalanine > alanine.

Reaction of P(III) chlorides with aldehydes: III. Reaction of primary intermediates with oxidants and chlorinating agents

Primary intermediates of P(III) chlorides reaction with aldehydes have been converted into the corresponding phosphates by treating with oxidants: dimethylsulfoxide and tert-butyl hypochlorite. In reactions of the intermediates with chlorinating agents (P

Studies on the interaction of phosphine selenides and their structural analogues wth dihalogens and sulfuryl chloride

The phosphine selenides, tris(dimethylamino)phosphine selenide, esters of selenophosphoric acid, and esters of selenophosphonic acid react with dihalogens and sulfuryl chloride to form halogenoselenophosphonium salts (≡ 3P-SeX)+X-. T

Reaction of Trichloro(o-phenylenedioxy)phosphorane with 1,2-Alkadienylphosphonates

Trichloro(o-phenylenedioxy)phosphorane reacts with 1,2-alkadienylphosphonates with selective replacement of the alkoxy group in the phosphinoyl moiety, yielding the corresponding 1,2-alkadienylchlorophosphonates and o-phenylene chlorophosphate.

Reaction of Trichloro(o-phenylenedioxy)phosphorane with Four-Coordinate Phosphorus Esters

Reactions of trialkyl phosphates and dialkyl alkenylphosphonates with trichloro(o-phenylenedioxy)phosphorane result in selective replacement of one alkoxy group on the phosphorus by a chlorine atom. Alkylphosphonates react with trichloro(o-phenylenedioxy)phosphorane to give alkyl alkylphosphonochloridates as the major products and small amounts of alkylphosphonic dichlorides.

Hypervalent tris(catecholato)silicate derived from rice hush ash

Rice husk ash with a particle size distribution between 2 and 7 μm reacts with catechol and sodium methoxide in methanol to afford the tris(catecholato)silicate, Na2[Si(o-C6H4O2)3] 1.

High yield synthesis of cyclic phosphites, phosphates, sulphites and sulphates of catechol and glycol mediated by hypervalent silicon centres

Room temperature reactions of both tris(catecholato)silicate, M2[Si(o-C6H4O2)3] {M=Na, Et3NH} and glycolato silicate, K2[Si2(O2C2H4)5] with PCl3, POCl3, SOCl2 and SO2Cl2 proceed exothermally and afford easy isolation of the corresponding cyclic derivatives of catechol/glycol (1-8) in high yield, exemplifying the merit of hypervalent silicon centres in synthesis. (Et3NH)2[Si(o-C6H4O2)3] afford near quantitative conversions.

Reaction of ortho-Phenylenedioxytrihalophosphoranes with Epichlorohydrin

Dynamic 31P NMR spectroscopy was applied to investigate the reactions of o-phenylenedioxytrihalophosphoranes and bis(o-phenylenedioxy)halophosphoranes with epichlorohydrin as a function of the reagent ratio. α-Opening of the epoxide ring predominantly occurs. With excess epichlorohydrin the reaction with o-phenylenedioxytrichlorophosphorane results in formation of pentaalkoxyphosphorane, while in the reaction with o-phenylenedioxytechintribromophosphorane a mixture of phosphate and pentaalkoxyphosphorane is formed.

PHOSPHORANES AND SPIROPHOSPHORANES CONTAINING A 1,3,2λ5-OXAZAPHOSPHETIDINE RING

Methods for synthesizing phosphoranes and spirophosporanes containing a 1,3,2λ5-oxazaphosphetidine ring from N-methyl-N-trifluoroacetylphosphoramidites were developed, and spectral characteristics of the products were studied.One of the phosphoranes prepared was studied by the x-ray diffraction method.