tert-butyl (3R,αS)-3-[N-(α-methylbenzyl)amino]-3-phenylpropanoate

Base Information

• Chemical Name: tert-butyl (3R,αS)-3-[N-(α-methylbenzyl)amino]-3-phenylpropanoate
• CAS No.: 146937-36-2
• Molecular Formula: C₂₁H₂₇NO₂
• Molecular Weight: 325.451
• Mol file: 146937-36-2.mol

Synonyms:tert-butyl (3R,αS)-3-[N-(α-methylbenzyl)amino]-3-phenylpropanoate

Chemical Property of tert-butyl (3R,αS)-3-[N-(α-methylbenzyl)amino]-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (3R,αS)-3-[N-(α-methylbenzyl)amino]-3-phenylpropanoate

There total 12 articles about tert-butyl (3R,αS)-3-[N-(α-methylbenzyl)amino]-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(R)-3-[Allyl-((S)-1-phenyl-ethyl)-amino]-3-phenyl-propionic acid tert-butyl ester (164660-15-5) → tert-butyl (3R,αS)-3-[N-(α-methylbenzyl)amino]-3-phenylpropanoate (146937-36-2)

Guidance literature:

With Wilkinson's catalyst; In water; acetonitrile;

DOI:10.1039/c39950001109

Reference yield: 86.0%

tert-butyl (3R,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate (265669-72-5) → tert-butyl (3R,αS)-3-[N-(α-methylbenzyl)amino]-3-phenylpropanoate (146937-36-2)

Guidance literature:

With ammonium cerium(IV) nitrate; water; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1039/b000071j

Reference yield: 65.0%

N-benzylidene-(S)-α-methylbenzylamine (69350-13-6) + 1-tert-butoxy-1-(trimethylsiloxy)ethylene (93215-51-1) → tert-butyl (3R,αS)-3-[N-(α-methylbenzyl)amino]-3-phenylpropanoate (146937-36-2)

Guidance literature:

With (R)-binaphthol; 4 A molecular sieve; triphenylborane; In dichloromethane; at -78 ℃; for 12h;

DOI:10.1021/ja00102a019

upstream raw materials:

N-benzylidene-(S)-α-methylbenzylamine

1-tert-butoxy-1-(trimethylsiloxy)ethylene

(R)-3-[Allyl-((S)-1-phenyl-ethyl)-amino]-3-phenyl-propionic acid tert-butyl ester

tert-butyl (3R,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate

Downstream raw materials:

(4R,αS)-N(1)-(α-methylbenzyl)-4-phenylazetidin-2-one