phenylmethyl [2-((1S,4S)-5-{(2S)-2-[(1H-indol-2-ylcarbonyl)amino]-3,3-dimethylbutanoyl}-2,5-diazabicyclo[2.2.1]hept-2-yl)-2-oxoethyl]carbamate

Base Information

Chemical Name:phenylmethyl [2-((1S,4S)-5-{(2S)-2-[(1H-indol-2-ylcarbonyl)amino]-3,3-dimethylbutanoyl}-2,5-diazabicyclo[2.2.1]hept-2-yl)-2-oxoethyl]carbamate
CAS No.:1186643-79-7
Molecular Formula:C₃₀H₃₅N₅O₅
Molecular Weight:545.638
Hs Code.:

Synonyms:phenylmethyl [2-((1S,4S)-5-{(2S)-2-[(1H-indol-2-ylcarbonyl)amino]-3,3-dimethylbutanoyl}-2,5-diazabicyclo[2.2.1]hept-2-yl)-2-oxoethyl]carbamate

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Chemical Property of phenylmethyl [2-((1S,4S)-5-{(2S)-2-[(1H-indol-2-ylcarbonyl)amino]-3,3-dimethylbutanoyl}-2,5-diazabicyclo[2.2.1]hept-2-yl)-2-oxoethyl]carbamate

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Technology Process of phenylmethyl [2-((1S,4S)-5-{(2S)-2-[(1H-indol-2-ylcarbonyl)amino]-3,3-dimethylbutanoyl}-2,5-diazabicyclo[2.2.1]hept-2-yl)-2-oxoethyl]carbamate

There total 6 articles about phenylmethyl [2-((1S,4S)-5-{(2S)-2-[(1H-indol-2-ylcarbonyl)amino]-3,3-dimethylbutanoyl}-2,5-diazabicyclo[2.2.1]hept-2-yl)-2-oxoethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 1186643-85-5
C₂₁H₃₀N₄O₄

: 1186643-79-7
phenylmethyl [2-((1S,4S)-5-{(2S)-2-[(1H-indol-2-ylcarbonyl)amino]-3,3-dimethylbutanoyl}-2,5-diazabicyclo[2.2.1]hept-2-yl)-2-oxoethyl]carbamate

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 1186643-79-7
phenylmethyl [2-((1S,4S)-5-{(2S)-2-[(1H-indol-2-ylcarbonyl)amino]-3,3-dimethylbutanoyl}-2,5-diazabicyclo[2.2.1]hept-2-yl)-2-oxoethyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 24 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h

3: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 24 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / dichloromethane / 2 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 113451-59-5,174823-32-6
(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

: 1186643-79-7
phenylmethyl [2-((1S,4S)-5-{(2S)-2-[(1H-indol-2-ylcarbonyl)amino]-3,3-dimethylbutanoyl}-2,5-diazabicyclo[2.2.1]hept-2-yl)-2-oxoethyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 24 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h

3: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 24 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / dichloromethane / 2 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In dichloromethane;