(S)-2-(2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxypropoxy)ethyl)isoindoline-1,3-dione

Base Information

• Chemical Name: (S)-2-(2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxypropoxy)ethyl)isoindoline-1,3-dione
• CAS No.: 1566613-74-8
• Molecular Formula: C₃₄H₃₃NO₇
• Molecular Weight: 567.639

Synonyms:(S)-2-(2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxypropoxy)ethyl)isoindoline-1,3-dione

Chemical Property of (S)-2-(2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxypropoxy)ethyl)isoindoline-1,3-dione

Chemical Property:

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Technology Process of (S)-2-(2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxypropoxy)ethyl)isoindoline-1,3-dione

There total 2 articles about (S)-2-(2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxypropoxy)ethyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + (R)-2-(2-(2,3-dihydroxypropoxy)ethyl)isoindoline-1,3-dione (1566613-73-7) → (S)-2-(2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxypropoxy)ethyl)isoindoline-1,3-dione (1566613-74-8)

Guidance literature:

With pyridine; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jo402704z

Reference yield:

N-(2-Hydroxyethyl)phthalimide (3891-07-4) → (S)-2-(2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxypropoxy)ethyl)isoindoline-1,3-dione (1566613-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: cesium fluoride / 24 h / 135 °C / Inert atmosphere

2: pyridine / 4 h / 20 °C / Inert atmosphere

With pyridine; cesium fluoride;

DOI:10.1021/jo402704z

Reference yield: 96.0%

(S)-2-(2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxypropoxy)ethyl)isoindoline-1,3-dione (1566613-74-8) → (S)-1-(2-aminoethoxy)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propan-2-ol (1566613-76-0)

Guidance literature:

With methylamine; In ethanol; at 78 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/jo402704z

upstream raw materials:

4,4'-dimethoxytrityl chloride

(R)-2-(2-(2,3-dihydroxypropoxy)ethyl)isoindoline-1,3-dione

N-(2-Hydroxyethyl)phthalimide

Downstream raw materials:

(S)-2-(2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxypropoxy)ethyl)-7-methylbenzo[lmn][3 ,8 ]-phenanthroline-1,3,6,8(2H,7H)-tetraone

(S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(2-(7-methyl-1,3,6,8-tetraoxo-7,8-dihydrobenzo[lmn][3,8]phenanthrolin-2(1H,3H,6H)-yl)ethoxy)propan-2-yl (2-cyanoethyl) N,N-diisopropylphosphoramidite

(S)-1-(2-aminoethoxy)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propan-2-ol

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