6-METHYLIMIDAZO[1,2-B]PYRIDAZINE

Base Information

• Chemical Name: 6-METHYLIMIDAZO[1,2-B]PYRIDAZINE
• CAS No.: 17412-38-3
• Molecular Formula: C₇H₇N₃
• Molecular Weight: 133.153
• Hs Code.: 2933990090
• Mol file: 17412-38-3.mol

Synonyms:6-Methylimidazo[1,2-b]pyridazine

Chemical Property of 6-METHYLIMIDAZO[1,2-B]PYRIDAZINE

Chemical Property:

• Refractive Index: 1.659
• PSA: 30.19000
• Density: 1.24g/cm3
• LogP: 1.03770

Purity/Quality:

98%min ^*data from raw suppliers

6-Methylimidazo[1,2-b]pyridazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-METHYLIMIDAZO[1,2-B]PYRIDAZINE

There total 3 articles about 6-METHYLIMIDAZO[1,2-B]PYRIDAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-chloroethanal (107-20-0) + 3-amino-6-methylpyridazine (18591-87-2,18591-82-7) → 6-methylimidazo[1,2-b]pyridazine (17412-38-3)

Guidance literature:

In water; butan-1-ol; for 4h; Reflux;

DOI:10.1021/jm500342d

Reference yield: 37.0%

dihydroxy-methyl-borane (13061-96-6) + 6-chloroimidazo[1,2-b]pyridazine (6775-78-6) → 6-methylimidazo[1,2-b]pyridazine (17412-38-3)

Guidance literature:

With potassium phosphate; palladium diacetate; In toluene; at 150 ℃; for 3h; Inert atmosphere;

Reference yield:

→ 6-methylimidazo[1,2-b]pyridazine (17412-38-3)

Guidance literature:

Brom-acetaldehyd-diethylacetal, 3-Amino-6-methyl-pyridazin, HBr3;

DOI:10.1016/S0040-4020(01)82537-0

upstream raw materials:

2-chloroethanal

3-amino-6-methylpyridazine

dihydroxy-methyl-borane

6-chloroimidazo[1,2-b]pyridazine

Downstream raw materials:

3-bromo-6-methylimidazo[1,2-b]pyridazine

Refernces

• 1、 Chapman, Timothy M.,Osborne, Simon A.,Wallace, Claire,Birchall, Kristian,Bouloc, Nathalie,Jones, Hayley M.,Ansell, Keith H.,Taylor, Debra L.,Clough, Barbara,Green, Judith L.,Holder, Anthony A.. "Optimization of an imidazopyridazine series of inhibitors of plasmodium falciparum calcium-dependent protein kinase 1 (Pf CDPK1)". . p. 3570 - 3587. Retrieved 2014/05/20.