(S)-2-(benzyloxycarbonylamino)-3-methyl-1,3-bis(trimethylsilyloxy)butane

Base Information

Chemical Name:(S)-2-(benzyloxycarbonylamino)-3-methyl-1,3-bis(trimethylsilyloxy)butane
CAS No.:372137-97-8
Molecular Formula:C₁₉H₃₅NO₄Si₂
Molecular Weight:397.662
Hs Code.:

Synonyms:(S)-2-(benzyloxycarbonylamino)-3-methyl-1,3-bis(trimethylsilyloxy)butane

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Chemical Property of (S)-2-(benzyloxycarbonylamino)-3-methyl-1,3-bis(trimethylsilyloxy)butane

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Technology Process of (S)-2-(benzyloxycarbonylamino)-3-methyl-1,3-bis(trimethylsilyloxy)butane

There total 3 articles about (S)-2-(benzyloxycarbonylamino)-3-methyl-1,3-bis(trimethylsilyloxy)butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 75-77-4
chloro-trimethyl-silane

: 174741-42-5
(S)-2-[[(benzyloxy)carbonyl]amino]-3-methyl-1,3-butanediol

: 372137-97-8
(S)-2-(benzyloxycarbonylamino)-3-methyl-1,3-bis(trimethylsilyloxy)butane

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; at 0 ℃; for 16h;
DOI:10.1002/1099-0690(200108)2001:16<3067::AID-EJOC3067>3.0.CO;2-0

Reference yield:

: 1676-81-9
N-benzyloxycarbonyl-L-serine methyl ester

: 372137-97-8
(S)-2-(benzyloxycarbonylamino)-3-methyl-1,3-bis(trimethylsilyloxy)butane

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / magnesium / diethyl ether; tetrahydrofuran / 1.5 h / 20 °C

2: 96 percent / imidazole / tetrahydrofuran / 16 h / 0 °C

With 1H-imidazole; magnesium; In tetrahydrofuran; diethyl ether;
DOI:10.1002/1099-0690(200108)2001:16<3067::AID-EJOC3067>3.0.CO;2-0

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 372137-97-8
(S)-2-(benzyloxycarbonylamino)-3-methyl-1,3-bis(trimethylsilyloxy)butane

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / aqueous sodium hydrogen carbonate / 4 h / 20 °C

2: 80 percent / 16 h / Heating

3: 83 percent / magnesium / diethyl ether; tetrahydrofuran / 1.5 h / 20 °C

4: 96 percent / imidazole / tetrahydrofuran / 16 h / 0 °C

With 1H-imidazole; sodium hydrogencarbonate; magnesium; In tetrahydrofuran; diethyl ether;
DOI:10.1002/1099-0690(200108)2001:16<3067::AID-EJOC3067>3.0.CO;2-0