TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACID DIETHYL ESTER

Base Information

• Chemical Name: TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACID DIETHYL ESTER
• CAS No.: 17351-22-3
• Molecular Formula: C₁₂H₂₀O₄
• Molecular Weight: 228.288
• Hs Code.: 2917209090
• Mol file: 17351-22-3.mol

Synonyms:1,2-Cyclohexanedicarboxylicacid, diethyl ester, (1R,2R)-rel- (9CI); 1,2-Cyclohexanedicarboxylic acid,diethyl ester, trans- (8CI); 1,2-Cyclohexanedicarboxylic acid, trans-, diethylester (5CI); trans-Diethyl 1,2-cyclohexanedicarboxylate

Chemical Property of TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACID DIETHYL ESTER

Chemical Property:

• Refractive Index: 1.46
• Boiling Point: 104 °C
• PSA: 52.60000
• Density: 1.04
• LogP: 1.91900

Purity/Quality:

98%,99%, ^*data from raw suppliers

Diethyl trans-1,2-Cyclohexanedicarboxylate >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACID DIETHYL ESTER

There total 19 articles about TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACID DIETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

diethyl 1,2,3,6-tetrahydrophthalate (13043-60-2) → diethyl 1,2-cyclohexanedicarboxylate (10138-59-7,17351-22-3)

Guidance literature:

With cobalt; In tetrahydrofuran; Heating; High pressure;

DOI:10.1039/c8cy00595h

Reference yield: 38.0%

diethyl suberate (2050-23-9) → diethyl 1,2-cyclohexanedicarboxylate (10138-59-7,17351-22-3)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 30h;

Reference yield: 31.0%

Diethyl phthalate (84-66-2) → diethyl 1,2-cyclohexanedicarboxylate (10138-59-7,17351-22-3)

Guidance literature:

With Ti₈O₈⁽¹⁴⁺⁾*6C₈H₄O₄^(2-)*4O^(2-)*3.3Li⁽¹⁺⁾*0.7Co⁽²⁺⁾*0.7C₄H₈O*0.7H^(1-); hydrogen; In neat (no solvent); at 160 ℃; for 18h; under 37503.8 Torr;

DOI:10.1021/jacs.7b11241

upstream raw materials:

ethanol

trans-1,2-cyclohexanedicarboxylic acid

(1R,2S)-cyclohexane-1,2-dicarboxylic acid

diethyl suberate

Downstream raw materials:

cis-1.2-bis-(α-hydroxy-benzhydryl)-cyclohexane

<2-Diphenylmethylen-cyclohexyl>-diphenyl-methanol

1,2-bis(hydroxymethyl)cyclohexane

1,1,3,3-tetramethyl-octahydro-isobenzofuran

Refernces

• 1、 Ji, Pengfei,Song, Yang,Drake, Tasha,Veroneau, Samuel S.,Lin, Zekai,Pan, Xiandao,Lin, Wenbin. "Titanium(III)-Oxo Clusters in a Metal-Organic Framework Support Single-Site Co(II)-Hydride Catalysts for Arene Hydrogenation". . p. 433 - 440. Retrieved 2018/01/17.
• 2、 Hu, Yancheng,Zhao, Zhitong,Liu, Yanting,Li, Guangyi,Wang, Aiqin,Cong, Yu,Zhang, Tao,Wang, Feng,Li, Ning. "Synthesis of 1,4-Cyclohexanedimethanol, 1,4-Cyclohexanedicarboxylic Acid and 1,2-Cyclohexanedicarboxylates from Formaldehyde, Crotonaldehyde and Acrylate/Fumarate". supporting information. p. 6901 - 6905. Retrieved 2018/06/04.