13043-60-2

Upstream product

• 106-99-0 buta-1,3-diene 
• 623-91-6 diethyl Fumarate 
• 77-79-2 3-Sulfolene 
• 64-17-5 ethanol 
• 1520-50-9 but-2-enedioic acid diethyl ester 
• 85-43-8 1,2,3,6-Tetrahydrophthalic anhydride 

Downstream Products

• 1262875-50-2 diethyl 1,2-diallylcyclohex-4-ene-1,2-dicarboxylate 
• 17351-07-4 diethyl cyclohexane-cis-1,2-dicarboxylate 
• 96836-97-4 diethyl cyclohexane-trans-1,2-dicarboxylate 
• 15679-28-4 ((1R,6R)-6-(hydroxymethyl)cyclohex-3-enyl)methanol 
• 14246-80-1 (1S*,2S*)-cyclohex-4-ene-1,2-dicarbohydrazide 
• 3470-42-6 trans-8-oxabicyclo<4.3.0>non-3-ene 
• 118374-48-4 (1S,2S,4S,5S)-4-Acetoxy-5-phenylselanyl-cyclohexane-1,2-dicarboxylic acid diethyl ester 
• 10138-59-7 diethyl 1,2-cyclohexanedicarboxylate 
• 84-66-2 Diethyl phthalate 
• 18418-41-2 Trimethylamin-carboximidyl-2-ethoxycarbonyl-cyclohex-4-en 
• 118374-49-5 C₂₀H₂₆Cl₂O₆Se 
• 118270-85-2 (1S,2S,5S)-5-Acetoxy-cyclohex-3-ene-1,2-dicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

Crown ethers derived from cyclohexane. Influence of their stereochemistry in complexation and transport

Crown ethers derived from cyclohexane have been prepared. The trans stereochemistry of the substituents on the carbocyclic ring makes that only one conformation can complex cations. The influence of the stereochemistry in complexation has been studied.

Synthesis of 1,4-Cyclohexanedimethanol, 1,4-Cyclohexanedicarboxylic Acid and 1,2-Cyclohexanedicarboxylates from Formaldehyde, Crotonaldehyde and Acrylate/Fumarate

Valuable polyester monomers and plasticizers—1,4-cyclohexanedimethanol (CHDM), 1,4-cyclohexanedicarboxylic acid (CHDA), and 1,2-cyclohexanedicarboxylates—have been prepared by a new strategy. The synthetic processes involve a proline-catalyzed formal [3+1+2] cycloaddition of formaldehyde, crotonaldehyde, and acrylate (or fumarate). CHDM is produced after a subsequent hydrogenation step over a commercially available Cu/Zn/Al catalyst and a one-pot hydrogenation/oxidation/hydrolysis process yields CHDA, whereas 1,2-cyclohexanedicarboxylate is obtained by a Pd/C-catalyzed tandem decarbonylation/hydrogenation step.

Methods for preparing 1,2-cyclohexanedicarboxylate or phthalic acid ester

The invention relates to methods for preparing a plasticizer 1,2-cyclohexanedicarboxylate and phthalic acid ester by a biomass route. The preparation method of 1,2-cyclohexanedicarboxylate comprises the following steps: 1. crotonaldehyde, formaldehyde and fumarate (or maleate) are subjected to a D-A cycloaddition reaction under the catalysis of organic base so as to generate diester-substituted cyclohexenecarboxaldehyde; 2. the product is subjected to decarbonylation under a transition metal catalyst to generate cyclohexenedicarboxylate; and 3. cyclohexenedicarboxylate undergoes hydrogenationof a double bond under a transition metal catalyst to generate 1,2-cyclohexanedicarboxylate. The preparation method of phthalic acid ester comprises the following steps: 1. crotonaldehyde, formaldehyde and fumarate (or maleate) are subjected to a D-A cycloaddition reaction under the catalysis of organic base so as to generate diester-substituted cyclohexenecarboxaldehyde; and 2. the product undergoes decarbonylation/aromatization under a transition metal catalyst to generate phthalic acid ester.

Novel carbocyclic nucleoside analogs suppress glomerular mesangial cells proliferation and matrix protein accumulation through ROS-dependent mechanism in the diabetic milieu

The synthesis of a series of novel 3,4-cis- and 3,4-trans-substituted carbocyclic nucleoside analogs from protected uracil and thymine is described. The key reaction in the followed synthetic protocols utilized the Mitsunobu reaction to couple 3,4-substit

[6+5] FUSED BICYCLES AS A THROMBIN ANTAGONIST, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE BICYCLES

The present invention relates to the new [6+5] fused bicycle derivatives, pharmaceutically acceptable salts or isomers thereof, processes for preparing the same, and pharmaceutical compositions comprising the same. The [6+5] fused bicycle derivatives can antagonize the thrombin receptor and thus may be effectively used for the treatment and prevention of thrombus, platelet aggregation, atherosclerosis, restenosis, blood coagulation, hypertension, arrhythmia, angina pectoris, heart failure, inflammation and cancer when used alone or with other cardiovascular agents.

Synthetic approach to cis and trans-decalins via Diels - Alder reaction and ring-closing metathesis as key steps: Further extension to dioxapropellane derivative by ring-closing metathesis

9,10-Substituted cis and trans-decalins were synthesized by a simple route using the Diels-Alder reaction and ring-closing metathesis (RCM) as key steps. Later, the cis-decalin system has been extended to 3,8-dioxa[8.4.4]propellane derivative by RCM sequence as a key step. Copyright

INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES

Disclosure is provided for imidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.

Triflimide activation of a chiral oxazaborolidine leads to a more general catalytic system for enantioselective Diels-Alder addition

The strong acid triflimide ((CF3SO2)2NH) protonates chiral oxazaborolidines to form superactive, stable, chiral Lewis acids which are highly effective catalysts for a wide variety of enantioselective Diels-Alder reactions, documented herein by more than 20 examples. Copyright

A Useful Preparation of Pyrroles from α,β-unsaturated Sulfones

The addition of alkyl isocyanoacetate to α,β-unsaturated sulfones, which are easily obtained from olefins, affords a convenient access to pyrroles with unusual substitution patterns.

Conformational Equilibrium in 8-Methyl-cis-2-thiahydrindane and 8-Methyl-cis-2-oxahydrindane by 13C NMR Spectroscopy

The preferred conformation of 8-methyl-cis-thiahydrindane has been both estimated by 13C NMR chemical shifts and determined by low temperature 13C NMR spectroscopy to be the conformer with the methyl group equatorial with respect to the cyclohexane ring.This result is in disagreement with the interpretation of the temperature dependence of the CD spectra of (+) and (-) 8-methyl-cis-2-thiahydrindane, whereby the conformation with the methyl group axial with respect to the cyclohexane ring was claimed to be the preferred conformation.The preferred conformation of the related oxygen heterocycle, 8-methyl-cis-2-oxahydrindane, has been estimated by 13C NMR chemical shifts to be the conformer with the methyl group axial with respect to the cyclohexane ring.Possible reasons for these observations are discussed.