4-O-[α,4-bis(tert-butoxycarbonyl)-2-nitrobenzyl] 1-O-(tert-butyl) (R)-N-(tert-butoxycarbonyl)aspartate

Base Information

Chemical Name:4-O-[α,4-bis(tert-butoxycarbonyl)-2-nitrobenzyl] 1-O-(tert-butyl) (R)-N-(tert-butoxycarbonyl)aspartate
CAS No.:444667-14-5
Molecular Formula:C₃₀H₄₄N₂O₁₂
Molecular Weight:624.686
Hs Code.:

Synonyms:4-O-[α,4-bis(tert-butoxycarbonyl)-2-nitrobenzyl] 1-O-(tert-butyl) (R)-N-(tert-butoxycarbonyl)aspartate

Suppliers and Price of 4-O-[α,4-bis(tert-butoxycarbonyl)-2-nitrobenzyl] 1-O-(tert-butyl) (R)-N-(tert-butoxycarbonyl)aspartate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-O-[α,4-bis(tert-butoxycarbonyl)-2-nitrobenzyl] 1-O-(tert-butyl) (R)-N-(tert-butoxycarbonyl)aspartate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-O-[α,4-bis(tert-butoxycarbonyl)-2-nitrobenzyl] 1-O-(tert-butyl) (R)-N-(tert-butoxycarbonyl)aspartate

There total 6 articles about 4-O-[α,4-bis(tert-butoxycarbonyl)-2-nitrobenzyl] 1-O-(tert-butyl) (R)-N-(tert-butoxycarbonyl)aspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99-75-2
4-methyl-benzoic acid methyl ester

: 444667-14-5
4-O-[α,4-bis(tert-butoxycarbonyl)-2-nitrobenzyl] 1-O-(tert-butyl) (R)-N-(tert-butoxycarbonyl)aspartate

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / Br₂ / benzene / 2 h / Irradiation

2: 74 percent / ethanol; H₂O / 3 h / Heating

3: 87 percent / sulfuric acid / H₂O / 5 °C

4: 70 percent / nitric acid; sulfuric acid / 3 h / 20 °C

5: 57 percent / 4-dimethylaminopyridin; N,N-dicyclohexylcarbodiimide / CCl₄ / 0.5 h / 0 °C

6: 34 percent / N-bromosuccinimide; dibenzoylperoxide / CCl₄ / 12 h / Heating

7: 58 percent / DBU / benzene / 5 h / Heating

With dmap; N-Bromosuccinimide; sulfuric acid; bromine; nitric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; dibenzoyl peroxide; In tetrachloromethane; ethanol; water; benzene;
DOI:10.1002/1099-0690(200203)2002:6<1037::AID-EJOC1037>3.0.CO;2-4

Reference yield:

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 444667-14-5
4-O-[α,4-bis(tert-butoxycarbonyl)-2-nitrobenzyl] 1-O-(tert-butyl) (R)-N-(tert-butoxycarbonyl)aspartate

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / ethanol; H₂O / 3 h / Heating

2: 87 percent / sulfuric acid / H₂O / 5 °C

3: 70 percent / nitric acid; sulfuric acid / 3 h / 20 °C

4: 57 percent / 4-dimethylaminopyridin; N,N-dicyclohexylcarbodiimide / CCl₄ / 0.5 h / 0 °C

5: 34 percent / N-bromosuccinimide; dibenzoylperoxide / CCl₄ / 12 h / Heating

6: 58 percent / DBU / benzene / 5 h / Heating

With dmap; N-Bromosuccinimide; sulfuric acid; nitric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; dibenzoyl peroxide; In tetrachloromethane; ethanol; water; benzene;
DOI:10.1002/1099-0690(200203)2002:6<1037::AID-EJOC1037>3.0.CO;2-4

Reference yield:

: 501-89-3
4-(carboxymethyl)benzoic acid

: 444667-14-5
4-O-[α,4-bis(tert-butoxycarbonyl)-2-nitrobenzyl] 1-O-(tert-butyl) (R)-N-(tert-butoxycarbonyl)aspartate

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / nitric acid; sulfuric acid / 3 h / 20 °C

2: 57 percent / 4-dimethylaminopyridin; N,N-dicyclohexylcarbodiimide / CCl₄ / 0.5 h / 0 °C

3: 34 percent / N-bromosuccinimide; dibenzoylperoxide / CCl₄ / 12 h / Heating

4: 58 percent / DBU / benzene / 5 h / Heating

With dmap; N-Bromosuccinimide; sulfuric acid; nitric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; dibenzoyl peroxide; In tetrachloromethane; benzene;
DOI:10.1002/1099-0690(200203)2002:6<1037::AID-EJOC1037>3.0.CO;2-4