5-CHLOROMETHYL-1-METHYL-1H-IMIDAZOLE HCL

Base Information

• Chemical Name: 5-CHLOROMETHYL-1-METHYL-1H-IMIDAZOLE HCL
• CAS No.: 17289-30-4
• Molecular Formula: C5H7 Cl N2 . Cl H
• Molecular Weight: 167.038
• Hs Code.: 2933290090
• Mol file: 17289-30-4.mol

Synonyms:1H-Imidazole,4-(chloromethyl)-1-methyl-, monohydrochloride (9CI); Imidazole, 4-(chloromethyl)-1-methyl-,monohydrochloride (8CI); 1-Methyl-4-chloromethylimidazole hydrochloride;4-(Chloromethyl)-1-methyl-1H-imidazole hydrochloride;4-(Chloromethyl)-1-methylimidazole hydrochloride

Chemical Property of 5-CHLOROMETHYL-1-METHYL-1H-IMIDAZOLE HCL

Chemical Property:

• Melting Point: 153-154 °C
• PSA: 17.82000
• LogP: 5.46210
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-(Chloromethyl)-1-methyl-1H-imidazoleHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLOROMETHYL-1-METHYL-1H-IMIDAZOLE HCL

There total 2 articles about 5-CHLOROMETHYL-1-METHYL-1H-IMIDAZOLE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.81%

hydroxymethylene-4 N-methylimidazole (17289-25-7) → 4-(chloromethyl)-1-methyl-1H-imidazole hydrochloride (17289-30-4)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 20 ℃; Heating / reflux;

Reference yield:

→ 4-(chloromethyl)-1-methyl-1H-imidazole hydrochloride (17289-30-4)

Guidance literature:

Reference yield: 26.0%

4-(chloromethyl)-1-methyl-1H-imidazole hydrochloride (17289-30-4) + 7-methyl-3-(2-(4-hydroxy-phenyl)-pyridin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[1,2-a]pyridine (656239-66-6) → 7-methyl-2-(6-methyl-pyridin-2-yl)-3-[2-(4-((1-methyl-imidazol-4-yl)methyloxy)phenyl)-pyridin-4-yl]-imidazo[1,2-a]pyridine (656240-13-0)

Guidance literature:

7-methyl-3-(2-(4-hydroxy-phenyl)-pyridin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[1,2-a]pyridine; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.333333h;

4-(chloromethyl)-1-methyl-1H-imidazole hydrochloride; In DMF (N,N-dimethyl-formamide); at 60 ℃; for 72h;

upstream raw materials:

hydroxymethylene-4 N-methylimidazole

Downstream raw materials:

7-methyl-2-(6-methyl-pyridin-2-yl)-3-[2-(4-((1-methyl-imidazol-4-yl)methyloxy)phenyl)-pyridin-4-yl]-imidazo[1,2-a]pyridine

Refernces

• 1、 -. "COMPOUNDS". Page 26. . Retrieved 2010/02/06.
• 2、 -. "COMPOUNDS". Page 23. . Retrieved 2010/11/30.