(2R,3S,4S)-2,3,4-tris(benzyloxy)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one

Base Information

Chemical Name:(2R,3S,4S)-2,3,4-tris(benzyloxy)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one
CAS No.:1431329-06-4
Molecular Formula:C₂H₂O₄*C₄₃H₅₂N₂O₇
Molecular Weight:798.931
Hs Code.:
Mol file:1431329-06-4.mol

Synonyms:(2R,3S,4S)-2,3,4-tris(benzyloxy)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one oxalate

Suppliers and Price of (2R,3S,4S)-2,3,4-tris(benzyloxy)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

TRC
(2R,3S,4S)-2,3,4-Tris(benzyloxy)-4-(4-((benzyloxy)-methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-oneOxalate
10mg
$ 1320.00

Total 11 raw suppliers

Chemical Property of (2R,3S,4S)-2,3,4-tris(benzyloxy)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(2R,3S,4S)-2,3,4-Tris(benzyloxy)-4-(4-((benzyloxy)-methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-oneOxalate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (2R,3S,4S)-2,3,4-Tris(benzyloxy)-4-(4-((benzyloxy)-methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one Oxalate is an antidiabetic agent and an Ertugliflozin (1210344-57-2) intermediate.

Technology Process of (2R,3S,4S)-2,3,4-tris(benzyloxy)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one

There total 2 articles about (2R,3S,4S)-2,3,4-tris(benzyloxy)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₀H₄₈N₂O₇

: 144-62-7,97993-78-7
oxalic acid

: 67-64-1
acetone

: 1431329-06-4
(2R,3S,4S)-2,3,4-tris(benzyloxy)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one oxalate

Guidance literature:: C₄₀H₄₈N₂O₇; acetone; With methanesulfonic acid; In toluene; Inert atmosphere;

oxalic acid;

Reference yield:

: 1431329-05-3
(2R,3S,4S)-2,3,4-tris(benzyloxy)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one

: 144-62-7,97993-78-7
oxalic acid

: 1431329-06-4
(2R,3S,4S)-2,3,4-tris(benzyloxy)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one oxalate

Guidance literature:: In tert-butyl methyl ether; at 50 ℃; for 2.16667h;
DOI:10.1021/op4002802

Reference yield:

: 1431329-06-4
(2R,3S,4S)-2,3,4-tris(benzyloxy)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one oxalate

: 1210344-83-4
(1S,2S,3S,4R,5S)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol (1:1) compound with (S)-5-oxopyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / toluene; water / 0.17 h / 20 °C

2.1: n-butyllithium / toluene; 2-methyltetrahydrofuran; hexane / -15 - 20 °C / Inert atmosphere

2.2: 0.17 h / -15 °C / Inert atmosphere

3.1: trifluoroacetic acid; triethylsilane / toluene / 20 °C

4.1: 5%-palladium/activated carbon; hydrogenchloride; hydrogen / toluene; methanol; water / 18 h / 25 °C / 2585.81 Torr / Inert atmosphere

5.1: methanol; water; isopropyl alcohol / 40 - 60 °C / 30 Torr

5.2: 40 - 80 °C

With hydrogenchloride; triethylsilane; n-butyllithium; 5%-palladium/activated carbon; hydrogen; sodium hydrogencarbonate; trifluoroacetic acid; In 2-methyltetrahydrofuran; methanol; hexane; water; isopropyl alcohol; toluene;
DOI:10.1021/op4002802