3-hydroxy-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)benzamide

Base Information

Chemical Name:3-hydroxy-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)benzamide
CAS No.:871656-69-8
Molecular Formula:C₁₆H₁₉N₃O₄
Molecular Weight:317.345
Hs Code.:

Synonyms:3-hydroxy-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-hydroxy-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)benzamide

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Technology Process of 3-hydroxy-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)benzamide

There total 7 articles about 3-hydroxy-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 871656-70-1
3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)-5-[(phenylmethyl)oxy]benzamide

: 871656-69-8
3-hydroxy-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)benzamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol;
DOI:10.1021/acs.oprd.8b00175

Reference yield:

: 5521-58-4
5-methylpyrazin-2-amine

: C₁₁H₁₃ClO₄

: 871656-69-8
3-hydroxy-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)benzamide

Guidance literature:: With pyridine; In acetonitrile; at 22 ℃;

Reference yield:

: 851885-42-2
methyl 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(phenylmethyl)oxy]benzoate

: 871656-69-8
3-hydroxy-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane

2.2: 0 - 20 °C

3.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol

With oxalyl dichloride; palladium 10% on activated carbon; hydrogen; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/acs.oprd.8b00175