Technology Process of (2E,4E)-5-(4-benzyloxy-3-methoxy-phenyl)-penta-2,4-dienoic acid ethyl ester
There total 6 articles about (2E,4E)-5-(4-benzyloxy-3-methoxy-phenyl)-penta-2,4-dienoic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium hydroxide;
In
tetrahydrofuran;
at 45 ℃;
for 3h;
Molecular sieve;
DOI:10.1039/b718787d
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 90 percent / diethyl ether / 2 h / 0 - 5 °C
2: 64 percent / phosphoryl chloride / 3 h / Heating
3: sodium hydride / 1,2-dimethoxy-ethane
With
sodium hydride; trichlorophosphate;
In
1,2-dimethoxyethane; diethyl ether;
1: Grignard reaction / 2: Condensation / 3: Wittig reaction;
DOI:10.1016/S0968-0896(99)00273-4
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 92 percent / potassium carbonate / acetone / 24 h / Heating
2: 90 percent / diethyl ether / 2 h / 0 - 5 °C
3: 64 percent / phosphoryl chloride / 3 h / Heating
4: sodium hydride / 1,2-dimethoxy-ethane
With
sodium hydride; potassium carbonate; trichlorophosphate;
In
1,2-dimethoxyethane; diethyl ether; acetone;
1: Etherification / 2: Grignard reaction / 3: Condensation / 4: Wittig reaction;
DOI:10.1016/S0968-0896(99)00273-4