(2E,4E)-5-(4-benzyloxy-3-methoxy-phenyl)-penta-2,4-dienoic acid ethyl ester

Base Information

Chemical Name:(2E,4E)-5-(4-benzyloxy-3-methoxy-phenyl)-penta-2,4-dienoic acid ethyl ester
CAS No.:178610-96-3
Molecular Formula:C₂₁H₂₂O₄
Molecular Weight:338.403
Hs Code.:

Synonyms:(2E,4E)-5-(4-benzyloxy-3-methoxy-phenyl)-penta-2,4-dienoic acid ethyl ester

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Chemical Property of (2E,4E)-5-(4-benzyloxy-3-methoxy-phenyl)-penta-2,4-dienoic acid ethyl ester

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Technology Process of (2E,4E)-5-(4-benzyloxy-3-methoxy-phenyl)-penta-2,4-dienoic acid ethyl ester

There total 6 articles about (2E,4E)-5-(4-benzyloxy-3-methoxy-phenyl)-penta-2,4-dienoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 42516-28-9
ethyl (2E)-4-(diethoxyphosphoryl)crotonate

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 178610-96-3
(2E,4E)-5-(4-benzyloxy-3-methoxy-phenyl)-penta-2,4-dienoic acid ethyl ester

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 45 ℃; for 3h; Molecular sieve;
DOI:10.1039/b718787d

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 178610-96-3
(2E,4E)-5-(4-benzyloxy-3-methoxy-phenyl)-penta-2,4-dienoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / diethyl ether / 2 h / 0 - 5 °C

2: 64 percent / phosphoryl chloride / 3 h / Heating

3: sodium hydride / 1,2-dimethoxy-ethane

With sodium hydride; trichlorophosphate; In 1,2-dimethoxyethane; diethyl ether; 1: Grignard reaction / 2: Condensation / 3: Wittig reaction;
DOI:10.1016/S0968-0896(99)00273-4

Reference yield:

: 100-39-0
benzyl bromide

: 178610-96-3
(2E,4E)-5-(4-benzyloxy-3-methoxy-phenyl)-penta-2,4-dienoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / potassium carbonate / acetone / 24 h / Heating

2: 90 percent / diethyl ether / 2 h / 0 - 5 °C

3: 64 percent / phosphoryl chloride / 3 h / Heating

4: sodium hydride / 1,2-dimethoxy-ethane

With sodium hydride; potassium carbonate; trichlorophosphate; In 1,2-dimethoxyethane; diethyl ether; acetone; 1: Etherification / 2: Grignard reaction / 3: Condensation / 4: Wittig reaction;
DOI:10.1016/S0968-0896(99)00273-4