N-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-yl)-3-(pyrrolidin-3-yl)benzamide hydrochloride

Base Information

Chemical Name:N-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-yl)-3-(pyrrolidin-3-yl)benzamide hydrochloride
CAS No.:1344033-83-5
Molecular Formula:C₂₆H₂₈N₆O*ClH
Molecular Weight:477.009
Hs Code.:

Synonyms:N-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-yl)-3-(pyrrolidin-3-yl)benzamide hydrochloride

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Chemical Property of N-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-yl)-3-(pyrrolidin-3-yl)benzamide hydrochloride

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Technology Process of N-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-yl)-3-(pyrrolidin-3-yl)benzamide hydrochloride

There total 7 articles about N-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-yl)-3-(pyrrolidin-3-yl)benzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1344034-13-4
tert-butyl 3-(3-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)phenyl)pyrrolidine-1-carboxylate

: 1344033-83-5
N-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-yl)-3-(pyrrolidin-3-yl)benzamide hydrochloride

Guidance literature:: With hydrogenchloride; methanol; for 0.5h;

Reference yield:

: 101066-61-9
2-chloropyridine-4-carbaldehyde

: 1344033-83-5
N-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-yl)-3-(pyrrolidin-3-yl)benzamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium metabisulfite / N,N-dimethyl-formamide / 18 h / 100 °C

2.1: triethylamine; diphenyl phosphoryl azide / toluene / 20 h / 20 °C / Reflux

2.2: 18 h / Reflux

3.1: acetic acid; hydrogen bromide / water; acetic acid / 0.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

5.1: dimethyl sulfoxide / 24 h / 140 °C / Sealed tube

6.1: hydrogenchloride; methanol / 0.5 h

With hydrogenchloride; methanol; sodium metabisulfite; diphenyl phosphoryl azide; hydrogen bromide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 603-81-6
2,3-diaminobenzoic acid

: 1344033-83-5
N-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-yl)-3-(pyrrolidin-3-yl)benzamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium metabisulfite / N,N-dimethyl-formamide / 18 h / 100 °C

2.1: triethylamine; diphenyl phosphoryl azide / toluene / 20 h / 20 °C / Reflux

2.2: 18 h / Reflux

3.1: acetic acid; hydrogen bromide / water; acetic acid / 0.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

5.1: dimethyl sulfoxide / 24 h / 140 °C / Sealed tube

6.1: hydrogenchloride; methanol / 0.5 h

With hydrogenchloride; methanol; sodium metabisulfite; diphenyl phosphoryl azide; hydrogen bromide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;