tert-butyl 3-(3-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)phenyl)pyrrolidine-1-carboxylate

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Chemical Name:tert-butyl 3-(3-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)phenyl)pyrrolidine-1-carboxylate
CAS No.:1344034-13-4
Molecular Formula:C₃₁H₃₆N₆O₃
Molecular Weight:540.665
Hs Code.:

Synonyms:tert-butyl 3-(3-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)phenyl)pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl 3-(3-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)phenyl)pyrrolidine-1-carboxylate

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Technology Process of tert-butyl 3-(3-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)phenyl)pyrrolidine-1-carboxylate

There total 6 articles about tert-butyl 3-(3-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)phenyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 107-10-8,42939-71-9
propylamine

: 1344034-12-3
tert-butyl 3-(3-(2-(2-chloropyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)phenyl)pyrrolidine-1-carboxylate

: 1344034-13-4
tert-butyl 3-(3-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)phenyl)pyrrolidine-1-carboxylate

Guidance literature:: In dimethyl sulfoxide; at 140 ℃; for 24h; Sealed tube;

Reference yield:

: 101066-61-9
2-chloropyridine-4-carbaldehyde

: 1344034-13-4
tert-butyl 3-(3-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)phenyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium metabisulfite / N,N-dimethyl-formamide / 18 h / 100 °C

2.1: triethylamine; diphenyl phosphoryl azide / toluene / 20 h / 20 °C / Reflux

2.2: 18 h / Reflux

3.1: acetic acid; hydrogen bromide / water; acetic acid / 0.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

5.1: dimethyl sulfoxide / 24 h / 140 °C / Sealed tube

With sodium metabisulfite; diphenyl phosphoryl azide; hydrogen bromide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1344034-03-2
benzyl 2-(2-chloropyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamate

: 1344034-13-4
tert-butyl 3-(3-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)phenyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; hydrogen bromide / water; acetic acid / 0.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

3: dimethyl sulfoxide / 24 h / 140 °C / Sealed tube

With hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;