Technology Process of trans-(R)-4-(1-aminoethyl)cyclohexanecarboxylic acid hydrochloride
There total 5 articles about trans-(R)-4-(1-aminoethyl)cyclohexanecarboxylic acid hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: chloroform / 0 °C
2: aluminum (III) chloride / 1,2-dichloro-ethane / 4 h / 20 - 60 °C
3: sodium hypochlorite; sodium hydroxide / methanol; water / 2 h / 20 - 60 °C
4: ruthenium on carbon; ammonia; hydrogen / water / 144 h / 90 - 150 °C / 52505.3 Torr
5: hydrogenchloride / water
With
hydrogenchloride; aluminum (III) chloride; sodium hypochlorite; ruthenium on carbon; ammonia; hydrogen; sodium hydroxide;
In
methanol; chloroform; water; 1,2-dichloro-ethane;
2: Friedel Crafts acylation;
DOI:10.1039/c1ob05332a
- Guidance literature:
-
Multi-step reaction with 4 steps
1: aluminum (III) chloride / 1,2-dichloro-ethane / 4 h / 20 - 60 °C
2: sodium hypochlorite; sodium hydroxide / methanol; water / 2 h / 20 - 60 °C
3: ruthenium on carbon; ammonia; hydrogen / water / 144 h / 90 - 150 °C / 52505.3 Torr
4: hydrogenchloride / water
With
hydrogenchloride; aluminum (III) chloride; sodium hypochlorite; ruthenium on carbon; ammonia; hydrogen; sodium hydroxide;
In
methanol; water; 1,2-dichloro-ethane;
1: Friedel Crafts acylation;
DOI:10.1039/c1ob05332a
