tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)(methyl)amino)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)(methyl)amino)piperidine-1-carboxylate
CAS No.:1403595-44-7
Molecular Formula:C₂₀H₂₉ClN₂O₄
Molecular Weight:396.914
Hs Code.:

Synonyms:tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)(methyl)amino)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)(methyl)amino)piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)(methyl)amino)piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)(methyl)amino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1403595-31-2
tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)-amino)-piperidine-1-carboxylate

: 74-88-4
methyl iodide

: 1403595-44-7
tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)(methyl)amino)piperidine-1-carboxylate

Guidance literature:: With caesium carbonate; In acetonitrile; at 80 ℃; for 12h;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1403595-44-7
tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)(methyl)amino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 23 °C

2: caesium carbonate / acetonitrile / 12 h / 80 °C

With sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; In dichloromethane; acetonitrile;

Reference yield:

: 154257-81-5
5-chloro-2-methyl-3-nitrobenzoic acid

: 1403595-44-7
tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)(methyl)amino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

2: water; ammonium chloride; iron / ethanol / 1 h / 80 °C

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 23 °C

4: caesium carbonate / acetonitrile / 12 h / 80 °C

With water; sodium tris(acetoxy)borohydride; iron; sodium carbonate; ammonium chloride; caesium carbonate; acetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;