tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)-amino)-piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)-amino)-piperidine-1-carboxylate
CAS No.:1403595-31-2
Molecular Formula:C₁₉H₂₇ClN₂O₄
Molecular Weight:382.887
Hs Code.:

Synonyms:tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)-amino)-piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)-amino)-piperidine-1-carboxylate

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Technology Process of tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)-amino)-piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)-amino)-piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 294190-18-4
methyl 3-amino-5-chloro-2-methylbenzoate

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1403595-31-2
tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)-amino)-piperidine-1-carboxylate

Guidance literature:: methyl 3-amino-5-chloro-2-methylbenzoate; N-tert-butyloxycarbonylpiperidin-4-one; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 23 ℃; for 18h;

With sodium hydrogencarbonate; In dichloromethane; water; Product distribution / selectivity;

Reference yield:

: 7499-06-1
5-chloro-2-methylbenzoic acid

: 1403595-31-2
tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)-amino)-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 0.17 h / -10 °C

1.2: 0.5 h / -10 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3.1: water; ammonium chloride; iron / ethanol / 1 h / 80 °C

4.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 23 °C

With sulfuric acid; water; sodium tris(acetoxy)borohydride; iron; sodium carbonate; ammonium chloride; acetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 294190-17-3
methyl 5-chloro-2-methyl-3-nitrobenzoate

: 1403595-31-2
tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)-amino)-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: water; ammonium chloride; iron / ethanol / 1 h / 80 °C

2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 23 °C

With water; sodium tris(acetoxy)borohydride; iron; ammonium chloride; acetic acid; In ethanol; dichloromethane;