N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-(1-piperazinylmethyl)-3-biphenylyl)acetamide

Base Information

Chemical Name:N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-(1-piperazinylmethyl)-3-biphenylyl)acetamide
CAS No.:1179344-51-4
Molecular Formula:C₃₅H₄₅N₇O₂
Molecular Weight:595.788
Hs Code.:

Synonyms:N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-(1-piperazinylmethyl)-3-biphenylyl)acetamide

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Chemical Property of N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-(1-piperazinylmethyl)-3-biphenylyl)acetamide

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Technology Process of N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-(1-piperazinylmethyl)-3-biphenylyl)acetamide

There total 6 articles about N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-(1-piperazinylmethyl)-3-biphenylyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₀H₅₃N₇O₄

: 1179344-51-4
N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-(1-piperazinylmethyl)-3-biphenylyl)acetamide

Guidance literature:: C₄₀H₅₃N₇O₄; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

amino cartridge;

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 1179344-51-4
N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-(1-piperazinylmethyl)-3-biphenylyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 1 h / 20 °C

2.1: water; potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3.2: amino cartridge

With water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; 2.1: Suzuki Coupling;

Reference yield:

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1179344-51-4
N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-(1-piperazinylmethyl)-3-biphenylyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tris(acetoxy)borohydride / dichloromethane / 17 h / 20 °C

2.1: water; potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3.2: amino cartridge

With water; sodium tris(acetoxy)borohydride; potassium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; 2.1: Suzuki Coupling;