3-[6-(4-iodophenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-1-yl]benzonitrile

Base Information

• Chemical Name: 3-[6-(4-iodophenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-1-yl]benzonitrile
• CAS No.: 385425-17-2
• Molecular Formula: C₂₀H₁₂F₃IN₄O
• Molecular Weight: 508.241

Synonyms:3-[6-(4-iodophenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-1-yl]benzonitrile

Chemical Property of 3-[6-(4-iodophenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-1-yl]benzonitrile

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of 3-[6-(4-iodophenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-1-yl]benzonitrile

There total 9 articles about 3-[6-(4-iodophenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-1-yl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.3%

→ 3-[6-(4-iodophenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-1-yl]benzonitrile (385425-17-2)

Guidance literature:

Reference yield:

1-(2-oxopiperidin-1-yl)-4-iodobenzene (385425-15-0) → 3-[6-(4-iodophenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-1-yl]benzonitrile (385425-17-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: PCl₃ / CHCl₃ / Heating

2.1: 140 °C

3.1: DMAP / CH₂Cl₂

4.1: aq. HCl / diethyl ether

5.1: methanol / Heating

5.2: TFA / CH₂Cl₂

With hydrogenchloride; dmap; phosphorus trichloride; In methanol; diethyl ether; dichloromethane; chloroform;

DOI:10.1016/j.bmcl.2006.08.027

Reference yield:

5-bromo-pentanoic acid-(4-iodophenyl)amide → 3-[6-(4-iodophenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-1-yl]benzonitrile (385425-17-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: t-BuOK

2.1: PCl₃ / CHCl₃ / Heating

3.1: 140 °C

4.1: DMAP / CH₂Cl₂

5.1: aq. HCl / diethyl ether

6.1: methanol / Heating

6.2: TFA / CH₂Cl₂

With hydrogenchloride; dmap; potassium tert-butylate; phosphorus trichloride; In methanol; diethyl ether; dichloromethane; chloroform;

DOI:10.1016/j.bmcl.2006.08.027

upstream raw materials:

1-(4-iodophenyl)-4-(2,2,2-trifluoroacetyl)-piperidine-2,3-dione

3-cyanophenyl hydrazine

1-(2-oxopiperidin-1-yl)-4-iodobenzene

3,3-dichloro-1-(4-iodophenyl)-piperidin-2-one

Downstream raw materials:

N-hydroxy-3-{7-oxo-6-[4-(2-oxo-2H-pyridin-1-yl)phenyl]-3-trifluoromethyl-4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-1-yl}benzamidine

N-methoxy-3-{7-oxo-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl}-benzamidine

3-{7-oxo-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-3-trifluoromethyl-4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-1-yl}benzamide

C₂₆H₂₂F₃N₇O

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