2,2'-[1-(diethoxyphosphinooxymethyl)-2-phenylethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

Base Information

Chemical Name:2,2'-[1-(diethoxyphosphinooxymethyl)-2-phenylethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]
CAS No.:1315454-24-0
Molecular Formula:C₂₅H₃₉N₂O₅P
Molecular Weight:478.569
Hs Code.:

Synonyms:2,2'-[1-(diethoxyphosphinooxymethyl)-2-phenylethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

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Chemical Property of 2,2'-[1-(diethoxyphosphinooxymethyl)-2-phenylethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

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Technology Process of 2,2'-[1-(diethoxyphosphinooxymethyl)-2-phenylethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

There total 4 articles about 2,2'-[1-(diethoxyphosphinooxymethyl)-2-phenylethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 589-57-1
diethyl phosphorylchloridite

: 1315454-21-7
2,2'-(1-hydroxymethyl-2-phenylethylidene)bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

: 1315454-24-0
2,2'-[1-(diethoxyphosphinooxymethyl)-2-phenylethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

Guidance literature:: With dmap; In toluene; for 18h; Inert atmosphere; Molecular sieve;
DOI:10.1016/j.tet.2011.05.079

Reference yield:

: 100-39-0
benzyl bromide

: 1315454-24-0
2,2'-[1-(diethoxyphosphinooxymethyl)-2-phenylethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 4 h / Inert atmosphere; Reflux

2.1: water; triethylamine / tetrahydrofuran; 1,4-dioxane; dichloromethane / 72 h / 20 °C / Inert atmosphere

3.1: dmap / toluene / 18 h / Inert atmosphere; Molecular sieve

With dmap; potassium tert-butylate; water; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;
DOI:10.1016/j.tet.2011.05.079

Reference yield:

: 131833-90-4,152754-11-5
2,2'-methylenebis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

: 1315454-24-0
2,2'-[1-(diethoxyphosphinooxymethyl)-2-phenylethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 4 h / Inert atmosphere; Reflux

2.1: water; triethylamine / tetrahydrofuran; 1,4-dioxane; dichloromethane / 72 h / 20 °C / Inert atmosphere

3.1: dmap / toluene / 18 h / Inert atmosphere; Molecular sieve

With dmap; potassium tert-butylate; water; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;
DOI:10.1016/j.tet.2011.05.079