5,6-DIHYDROXY-2-ISOPROPYL-PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 5,6-DIHYDROXY-2-ISOPROPYL-PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 954241-01-1
• Molecular Formula: C₉H₁₂N₂O₄
• Molecular Weight: 212.205
• Mol file: 954241-01-1.mol

Synonyms:methyl 5-hydroxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate

Chemical Property of 5,6-DIHYDROXY-2-ISOPROPYL-PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

5,6-Dihydroxy-2-isopropyl-pyrimidine-4-carboxylicAcidmethylester ^*data from reagent suppliers

Safty Information:

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MSDS Files:

SDS file from LookChem

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Technology Process of 5,6-DIHYDROXY-2-ISOPROPYL-PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER

There total 1 articles about 5,6-DIHYDROXY-2-ISOPROPYL-PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

dimethyl 2-(1-amino-2-methylpropylidenaminooxy)but-2-endioate (1350906-13-6) → methyl 5-hydroxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate (954241-01-1)

Guidance literature:

In o-xylene; for 48h; Reflux;

DOI:10.1021/acsmedchemlett.0c00009

Reference yield: 87.0%

methyl 5-hydroxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate (954241-01-1) + benzoic acid anhydride (93-97-0) → methyl 5-benzyloxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate (1350906-14-7)

Guidance literature:

With pyridine; at 20 ℃; for 48h;

DOI:10.1021/acsmedchemlett.0c00009

Reference yield:

methyl 5-hydroxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate (954241-01-1) → N-(4-benzoylbenzyl)-5-hydroxy-2-isopropyl-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine / 48 h / 20 °C

2.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide; water / 12 h / 50 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 4.5 h / 20 °C

With pyridine; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/acsmedchemlett.0c00009

upstream raw materials:

dimethyl 2-(1-amino-2-methylpropylidenaminooxy)but-2-endioate

Downstream raw materials:

N-(4-fluorobenzyl)-5-hydroxy-2-isopropyl-1-methyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate

methyl 5-benzyloxy-2-isopropyl-1-methyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate

methyl 5-benzyloxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate

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