methyl 5-benzyloxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate

Base Information

Chemical Name:methyl 5-benzyloxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate
CAS No.:1350906-14-7
Molecular Formula:C₁₆H₁₆N₂O₅
Molecular Weight:316.313
Hs Code.:

Synonyms:methyl 5-benzyloxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate

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Chemical Property of methyl 5-benzyloxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate

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Technology Process of methyl 5-benzyloxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate

There total 1 articles about methyl 5-benzyloxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 954241-01-1
methyl 5-hydroxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate

: 93-97-0
benzoic acid anhydride

: 1350906-14-7
methyl 5-benzyloxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate

Guidance literature:: With pyridine; at 20 ℃; for 48h;
DOI:10.1021/acsmedchemlett.0c00009

Reference yield: 98.0%

: 1350906-14-7
methyl 5-benzyloxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate

: 74-88-4
methyl iodide

: 1350906-15-8
methyl 5-benzyloxy-2-isopropyl-1-methyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate

Guidance literature:: methyl 5-benzyloxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate; With caesium carbonate; In tetrahydrofuran; at 20 ℃; for 0.333333h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.0c00009

Reference yield:

: 1350906-14-7
methyl 5-benzyloxy-2-isopropyl-6-oxo-1,6-dihydroxypyrimidine-4-carboxylate

: N-(4-benzoylbenzyl)-5-hydroxy-2-isopropyl-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

1.2: 24 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / 12 h / 50 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 4.5 h / 20 °C

With water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acsmedchemlett.0c00009